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Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

Nature volume 334, pages 676682 (25 August 1988) | Download Citation

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Abstract

Immunological tolerance has been demonstrated in double-transgenic mice expressing the genes for a neo-self antigen, hen egg lysozyme, and a high affinity anti-lysozyme antibody. The majority of anti-lysozyme B-cells did not undergo clonal deletion, but were no longer able to secrete anti-lysozyme antibody and displayed markedly reduced levels of surface IgM while continuing to express high levels of surface IgD. These findings indicate that self tolerance may result from mechanisms other than clonal deletion, and are consistent with the hypothesis that IgD may have a unique role in B-cell tolerance.

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Author information

Author notes

    • Thomas B. Lavoie
    •  & Sandra J. Smith-Gill

    Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

    • Kathy Raphael

    Division of Animal Production, CSIRO, Prospect, New South Wales, Australia

Affiliations

  1. Clinical Immunology Research Centre, University of Sydney, New South Wales 2006, Australia

    • Christopher C. Goodnow
    • , Jeffrey Crosbie
    • , Stephen Adelstein
    • , Thomas B. Lavoie
    • , Sandra J. Smith-Gill
    • , Robert A. Brink
    • , Helen Pritchard-Briscoe
    • , John S. Wotherspoon
    • , Robert H. Loblay
    • , Kathy Raphael
    • , Ronald J. Trent
    •  & Antony Basten

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https://doi.org/10.1038/334676a0

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