Mysteries of HIV: challenges for therapy and prevention

A number of problems still surround infection by the human immunodeficiency virus and the pathogenesis of AIDS. Solutions to the problems would provide valuable information for the development of antiviral therapy and a vaccine.

References

  1. 1

    Fauci, A. S. Science 239, 617–622 (1988).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Maddon, P. J. et al. Cell 47, 333–348 (1986).

    CAS  Article  Google Scholar 

  3. 3

    Cheng-Mayer, C. et al. Proc. natn. Acad. Sci. U.S.A. 84, 3526–3530 (1987).

    ADS  CAS  Article  Google Scholar 

  4. 4

    Tateno, M. & Levy, J. A. IV Int. Conf. AIDS, Stockholm (abstr.), (1988).

  5. 5

    Wiley, C. A. et al. Proc. natn. Acad. Sci. U.S.A. 88, 7089–7093 (1986).

    ADS  Article  Google Scholar 

  6. 6

    Nelson, J. A. et al. Lancet i, 259–262 (1988).

    Article  Google Scholar 

  7. 7

    Stein, B. S. et al. Cell 49, 659–668 (1987).

    CAS  Article  Google Scholar 

  8. 8

    Gallaher, W. R. Cell 50, 327–328 (1987).

    CAS  Article  Google Scholar 

  9. 9

    Chanh, T. C. et al. EMBO J. 5, 3065–3071 (1986).

    CAS  Article  Google Scholar 

  10. 10

    Robinson, W. E. et al. Lancet i, 790–795 (1988).

    Article  Google Scholar 

  11. 11

    Halstead, S. B. & O'Rourke, E. J. J. exp. Med. 146, 201–217 (1977).

    CAS  Article  Google Scholar 

  12. 12

    Ho, D. D. et al. Science 239, 1021–1023 (1988).

    ADS  CAS  Article  Google Scholar 

  13. 13

    Gartner, S. et al. Science 233, 215–219 (1986).

    ADS  CAS  Article  Google Scholar 

  14. 14

    Levy, J. A. et al. Ann. Inst. Pasteur 138, 101–111 (1987).

    CAS  Article  Google Scholar 

  15. 15

    Evans, L. A. et al. J. lmmun. 138, 3415–3418 (1987).

    CAS  Google Scholar 

  16. 16

    Levy J. A. et al. Science 232, 998–1001 (1986).

    ADS  CAS  Article  Google Scholar 

  17. 17

    Nabel, G & Baltimore, D. Nature 326, 711–713 (1987).

    ADS  CAS  Article  Google Scholar 

  18. 18

    Cheng-Mayer, C. et al. Science 240, 80–82 (1988).

    ADS  CAS  Article  Google Scholar 

  19. 19

    Hahn, B. H. et al. Science 232, 1548–1553 (1986).

    ADS  CAS  Article  Google Scholar 

  20. 20

    Starcich, B. R. et al. Cell 45, 637–648 (1986).

    CAS  Article  Google Scholar 

  21. 21

    Weiss, R. A. et al. Nature 324, 572–575 (1986).

    ADS  CAS  Article  Google Scholar 

  22. 22

    Evans, L. A. et al. Science 240, 1522–1525 (1988).

    ADS  CAS  Article  Google Scholar 

  23. 23

    Luciw, P. A. et al. Nature 312, 760–763 (1984).

    ADS  CAS  Article  Google Scholar 

  24. 24

    Robert-Guroff, M. et al. J. lmmun. 137, 3306–3309 (1986).

    CAS  Google Scholar 

  25. 25

    Carpenter, S. et al. J. Virol. 61, 3783–3789 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  26. 26

    Price, R. W. et al. Science 239, 586–592 (1988).

    ADS  CAS  Article  Google Scholar 

  27. 27

    Fontana, A. et al. Nature 307, 273–276 (1984).

    ADS  CAS  Article  Google Scholar 

  28. 28

    Cohen, M. B. & Beckstead, J. in AIDS: Pathogenesis and Treatment (ed. Levy, J. A.) (Dekker, New York, in the press).

  29. 29

    Harper, M. E. et al. Proc. natn. Acad. Sci. U.S.A. 83, 772–776 (1986).

    ADS  CAS  Article  Google Scholar 

  30. 30

    Hoxie, J. A. et al. Science 229, 1400–1402 (1985).

    ADS  CAS  Article  Google Scholar 

  31. 31

    Asjo, B et al. Lancet 2, 660–662 (1986).

    CAS  PubMed  Google Scholar 

  32. 32

    Koenig, S. & Fauci, A. S. in AIDS: Etiology, Diagnosis, Treatment and Prevention, 2nd edn. (eds DeVita, V., Hellman. S. & Rosenberg, S.) (Lippincott, Philadelphia, in the press).

  33. 33

    Laurence, J. et al. J. clin. Invest. 72, 2072–2081 (1983).

    CAS  Article  Google Scholar 

  34. 34

    Shalaby, M. R. et al. Cell lmmun. 110, 140–148 (1987).

    CAS  Article  Google Scholar 

  35. 35

    Stricker, R. B. et al. Nature 327, 710–713 (1987).

    ADS  CAS  Article  Google Scholar 

  36. 36

    Ziegler, J. & Stites, D. P. Clin. Immunol. Immunopathol. 41, 305–313 (1986).

    CAS  Article  Google Scholar 

  37. 37

    Donahue, R. E. et al. Nature 326, 200–203 (1987).

    ADS  CAS  Article  Google Scholar 

  38. 38

    Weinhold, K. J. et al. Lancet i, 902–904 (1988).

    Article  Google Scholar 

  39. 39

    Somasundaran, M. & Robinson, H. L. J. Virol. 61, 3114–3119 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  40. 40

    Hoxie, J. et al. Science 234, 1123–1127 (1986).

    ADS  CAS  Article  Google Scholar 

  41. 41

    Rasheed, S et al. Virology 154, 395–400 (1986).

    CAS  Article  Google Scholar 

  42. 42

    Gupta, S. & Vayuvegula, B. J. clin. lmmun. 7, 486 (1987).

    CAS  Article  Google Scholar 

  43. 43

    Lynn, W. S. et al. Virology 163, 43–51 (1988).

    CAS  Article  Google Scholar 

  44. 44

    Keshet, E. & Temin, H. M. J. Virol. 31, 376–388 (1979).

    CAS  PubMed  PubMed Central  Google Scholar 

  45. 45

    Rutherford, G. W. & Werdegar, D. in AIDS: Pathogenesis and Treatment (ed. Levy, J. A.) (Dekker, New York, in the press).

  46. 46

    Lang, W. et al. Abstr. Int. on Conf. AIDS, Stockholm abstr.) (1988).

  47. 47

    Walker, B. et al. Nature 328, 345–348 (1987).

    ADS  CAS  Article  Google Scholar 

  48. 48

    Plata, F. et al. Nature 328, 348–351 (1987).

    ADS  CAS  Article  Google Scholar 

  49. 49

    Walker, C. M. et al. Science 234, 1563–1566 (1986).

    ADS  CAS  Article  Google Scholar 

  50. 50

    Kannagi, M. et al. J. lmmun. 140, 2237–2242 (1988).

    CAS  Google Scholar 

  51. 51

    Lange, J. M. A. et al. Br. med. J. 293, 1459–1462 (1986).

    CAS  Article  Google Scholar 

  52. 52

    Mosca, J. D. et al. Proc. natn. Acad. Sci. U.S.A. 84, 7408–7412 (1987).

    ADS  CAS  Article  Google Scholar 

  53. 53

    Rojko, J. L. et al. Nature 298, 385–388 (1982).

    ADS  CAS  Article  Google Scholar 

  54. 54

    Folks, T. M. et al. Science 231, 600–602 (1986).

    ADS  CAS  Article  Google Scholar 

  55. 55

    Luciw, P. A. et al. Proc. natn. Acad. Sci. U.S.A. 84, 1434–1438 (1987).

    ADS  CAS  Article  Google Scholar 

  56. 56

    Guy, B. et al. Nature 330, 266–269 (1987).

    ADS  CAS  Article  Google Scholar 

  57. 57

    Farzadegan, H. et al. Ann. int. Med. 108, 785–790 (1988).

    CAS  Article  Google Scholar 

  58. 58

    Levy, J. A. J. Am. med. Ass. 259, 3037–3038 (1988).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Levy, J. Mysteries of HIV: challenges for therapy and prevention. Nature 333, 519–522 (1988). https://doi.org/10.1038/333519a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing