Abstract
Although inositol 1,3,4,5,6-pentakisphosphate (InsP5) and hexakisphosphate (InsP6) have been recognized for some time as naturally-occurring metabolites of inositol1, their occurence in mammalian cell types2–5, including one of neural origin6, has only recently been documented. This is of interest because of the recognized second messenger role of inositol 1,4,5-trisphosphate (InsP3) in intracellular signalling; coupling surface stimuli to cytoplasmic calcium discharge7. The metabolism, existence in normal mature tissues, and possible functional roles of these inositol polyphosphates are unknown. Here we report evidence that InsP5 and InsP6 are synthesized in intact brain after labelling with [3H]inositol in vivo. We also show that local infusion of InsP5 and InsP6 into a discrete brain stem nucleus implicated in cardiovascular regulation, results in dose-dependent changes in heart rate and blood pressure.
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References
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Vallejo, M., Jackson, T., Lightman, S. et al. Occurrence and extracellular actions of inositol pentakis- and hexakisphosphate in mammalian brain. Nature 330, 656–658 (1987). https://doi.org/10.1038/330656a0
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DOI: https://doi.org/10.1038/330656a0
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