Abstract
We have previously shown that vasoactive intestinal peptide (VIP) and noradrenaline (NA) interact synergistically to increase cyclic AMP levels in mouse cerebral cortical slices1. The pharmacological mechanism of this synergism is the potentiatioh by NA, through α1 adrenergic receptors, of the stimulatory effect of VIP on cAMP formation2. A similar interaction has been confirmed in guinea pig cerebral cortex3 and in discrete nuclei of the rat hypothalamus4. Furthermore VIP and NA interact synergistically to depress the spontaneous activity of identified neurons in rat neocortex5. At the cellular level, this synergistic interaction suggests that VIP-and NA-containing neuronal systems may converge, at least in part, on the same target cells to increase cAMP levels in the cerebral cortex. At the molecular level, the interaction may occur at various steps in signal transduction, between receptors, intramembrane transduction processes or intracellular effector mechanisms. Here we report that the α1-adrenergic potentiation of the increases in cAMP elicited by VIP involves the formation of arachidonic acid metabolites and is mimicked by prostglandins F2α and E2.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
To whom reprint requests should be addressed.
Rights and permissions
About this article
Cite this article
Schaad, N., Schorderet, M. & Magistretti, P. Prostaglandins and the synergism between VIP and noradrenaline in the cerebral cortex. Nature 328, 637–640 (1987). https://doi.org/10.1038/328637a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/328637a0
This article is cited by
-
Arachidonic acid metabolites as mediators of somatostatin-induced increase of neuronal M-current
Nature (1990)
-
Melatonin biosynthesis in the mammalian pineal gland
Experientia (1989)
-
Formation of second messengers in response to activation of ion channels in excitable cells
Cellular and Molecular Neurobiology (1988)
-
Interactions between prostaglandin E2 andd-ala2-met-enkephalinamide on adenylate cyclase activity in the guinea-pig superior cervical ganglion
Neurochemical Research (1988)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.