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Sequence of simian immunodeficiency virus and its relationship to the human immunodeficiency viruses

Nature volume 328, pages 539–543 (1987)Cite this article

Abstract

The characterization of HIV-1 (HTLV-III/LAV)1,2, the human retrovirus associated with AIDS (acquired immune deficiency syndrome) 3 has led to the identification of a group of related human and simian retroviruses which also infect CD4-bearing T lymphocytes. Simian T-lymphotropic virus type III (simian immodeficiency virus) from macaques (STLV-IIIMAC) induces symptoms similar to those of AIDS in infected macaques4,5, but isolates from African green monkeys (STLV-IIIAGM) 6 and mangabeys (STLV-IIMM) 7,8 appear to be non-pathogenic in these animals. A human virus immunologically related to STLV-IIIAGM (HTLV-IV), reported to have been isolated from healthy humans9, has been shown to be almost identical to STLV-IHAGM10,11, which has called into question the independent origin of these viruses11. Here we report the complete DNA sequence of STLV-IIIAGM and analyse its relationship with the genomes of the HTLV -IIIB strain of HIV-1, HIV-2ROD (previously called LAV-2) 12–15 and several ungulate lentiretroviruses. STLV-IIIAGM and HIV-2 are closely related, and more distantly related to HIV-1.

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References

  1. 1. Barre–Sinoussi, F. et al Science 220, 868–871 (1983). 2. Popovic, M. et al Science 224, 497–499 (1984). 3. Gottlieb, M. S. et al N. Engl J. Med. 305, 1425–1429 (1981). 4. Daniel, M. D. et al Science 228, 1201–1204 (1985). 5. Letvin, N. L. et al Science 230, 71–73 (1985). 6. Kanki, P. J., Alroy, J. & Essex, M. Science 230, 951–954 (1985). 7. Murphey–Corb, M. et al Nature 321, 435–437 (1986). 8. Fultz, P. N., et al Proc. natn. Acad. Sci. U.S.A. 83, 5286–5290 (1986). 9. Kanki, P. J., et al. Science 232, 238–242 (1986). 10. Franchini, G. et al. in AIDS Research and Human Retroviruses 3, 11–17 (1987). 11. Kornfeld, H., Riedel, N., Viglianti, A., Hirsch, V. & Mullins, J. I. Nature 326,610–613 (1987). 12. Clavel, F. et al Science 233, 343–346 (1986). 13. Albert, J. et al. in AIDS Research and Human Retroviruses 3, 2–10 (1987). 14. Clavel, F. et al. Nature 324, 691–695 (1986). 15. Guyder, M. et al. Nature 326, 662–669 (1987). 16. Ratner, L. et al. Nature 313, 277–284 (1985). 17. Sanchez–Pescador, R. et al Science 227, 484–492 (1985). 18. Muesing, M. A. et al Nature 313, 450–458 (1985). 19. Wain–Hobson, S., Sonigo, P., Danos, O., Cole, S. & Alizon, M. Cell 40, 9–17 (1985). 20. Ziff, E. B. & Evans, R. M. Cell 15, 1463–1475 (1978). 21. Proudfoot, N. J. & Brownlee, G. G. Nature 263, 211–214 (1976). 22. Guo, H.–G. et al in AIDS Research and Human Retroviruses (in the press). 23. Derse, D. et al J. Virol 61, 743–747 (1987). 24. Stephens, R. M., Casey, J. W. & Rice, N. R. Science 231, 589–594 (1986). 25. Seiki, M., Hattori, S., Hirayama, Y. & Yoshida, M. Proc. natn. Acad. Sci. U.S.A. 80,3618–3622 (1983). 26. Ratner, L. et al in AIDS Research and Human Retroviruses (in the press). 27. diMarzo Veronese, F. et al Science 231, 1289–1292 (1986). 28. Kan, N. C. et al Science 231, 1553–1555 (1986). 29. Arya, S. K., Guo, C., Joseph, S. F. & Wong–Staal, F. Science 229, 69–73 (1985). 30. Hirsh, V., Reidel, N. & Mullins, J. Cell 49, 307–319 (1987). 31. Fisher, A. G. et al. Science 233, 655–659 (1986). 32. diMarzo Veronese, F. et al. Science 229, 1402–1405 (1985). 33. Cease, K. B. et al. Proc. natn. Acad. Sci. U.S.A. 84, 4249 (1987). 34. Sodroski, J. et al. Nature 321, 412–417 (1986). 35. Feinberg, M. B., Jarrett, R. F., Aldovini, A., Gallo, R. C. & Wong–Staal, F. Cell46,807 (1986). 36. Knight, D. M., Flemterfelt, F. A. & Grayes, J. Science 236, 837–840 (1987). 37. Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).

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Authors and Affiliations

  1. Biotech Research Laboratory, Inc., Three Taft Court, Rockville, Maryland, 20850, USA

    K. A. Fargnoli

  2. Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA

    G. Franchini, H.-G. Guo, R. C. Gallo, E. Collalti, L. F. Hall, F. Wong-Staal & M. S. Reitz Jr

  3. Centre di Endocrinologia ed Oncologia Sperimentale del CNR Napoli, Italy

    C. Gurgo

  4. Dipartimento Di Medicina Sperimentale, II Cattedra Patologia Generale, Facolta Di Medicina E Chirurgia, Universita Degli Studi, La Sapienza, Rome, Italy

    E. Collalti

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  1. G. Franchini
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  2. C. Gurgo
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  9. M. S. Reitz Jr
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Franchini, G., Gurgo, C., Guo, HG. et al. Sequence of simian immunodeficiency virus and its relationship to the human immunodeficiency viruses. Nature 328, 539–543 (1987). https://doi.org/10.1038/328539a0

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