Abstract
Analysis of the nucleotide sequence of the human retrovirus associated with AIDS in West Africa, HIV-2, shows that it is evolutionary distant from the previously characterized HIV-1. We suggest that these viruses existed long before the current AIDS epidemics. Their biological properties are conserved in spite of limited sequence homology; this may help the determination of the structure–function relationships of the different viral elements.
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Guyader, M., Emerman, M., Sonigo, P. et al. Genome organization and transactivation of the human immunodeficiency virus type 2. Nature 326, 662–669 (1987). https://doi.org/10.1038/326662a0
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DOI: https://doi.org/10.1038/326662a0
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