Abstract
Regulation of transcription in eukaryotes is mediated by the specific interaction between cellular factors and promoter sequences1. Cis-acting DNA sequences, frequently located upstream of the TATA box, have been implicated in modulating the expression of many genes2. We are interested in the transcriptional regulation of proto-oncogenes because they may have a pivotal function in cell growth and differentiation3,4. Expression of the proto-oncogene c-fos is induced in response to a variety of growth factors and differentiation-specific agents4. The viral cognate of the c-fos gene is the resident transforming gene of FBJ-murine osteosarcoma virus which causes bone tumours in vivo and cellular transformation in vitro5,6. We report here that transcription of the human c-fos gene is modulated by negatively and positively acting cellular factors.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Sassone-Corsi, P. & Borrelli, E. Trends Getter. 2, 215–219 (1986).
Serfling, E., Jasin, M. & Schaffner, W. Trends Genet. 1, 224–230 (1985).
Muller, R. & Verma, I. M. Curr. Topics Microbiol. Immun. 112, 73–115 (1984).
Verma, I. M. Trends Genet. 2, 93–96 (1986).
Finkcl, M. P., Biskis, B. O. & Jinkins, P. B. Science 151, 698–701 (1966).
Miller, A. D., Curran, T. & Verma, I. M. Cell 36, 51–60 (1984).
Treisman, R. Cell 42, 889–902 (1985).
Deschamps, J. D., Meijlink, F. & Verma, I. M. Science 230, 1174–1177 (1985).
Renz, M., Neuberg, M., Kurz, C., Bravo, R. & Müller, R. EMBO J. 4, 3711–3716 (1985).
Gilman, M., Wilson, R. N. & Weinberg, R. W. Molec. cell. Biol. 6, 4305–4315 (1986).
Treisman, R. Cell 46, 567–574 (1986).
Van Straaten, F., Muller, R., Curran, C., Van Beveren, C. & Verma, I. M. Proc. natn. Acad. Sci. U.S.A. 80, 3183–3187 (1983).
Gorman, C. M., Moffat, L. F. & Howard, B. H. Molec. cell. Biol. 2, 1044–1051 (1980).
Verma, I. M., Deschamps, J., Van Beveren, C. & Sassone-Corsi, P. Cold Spring Harbor Symposium on Molecular Biology of Homosapiens (1986) (in the press).
Deschamps, J. et al. Cold Spring Harb. Symp. on Molecular Biology of Development 50, 733–745 (1985).
Greenberg, M. E., Hermanowski, A. L. & Ziff, E. B. Molec. cell. Biol. 6, 1050–1057 (1986).
Mitchell, R. L., Henning-Chubb, C., Huberman, E. & Verma, I. M. Cell 45, 497–504 (1986).
Scholer, H. & Grass, P. Cell 36, 403–411 (1984).
Sassone-Corsi, P., Wildemann, A. & Chambon, P. Nature 313, 458–463 (1985).
Welher, H., Konig, M. & Grass, P. Science 219, 626–631 (1983).
Gorman, C. M., Rigby, P. W. J. & Lane, D. P. Cell 42, 519–526 (1985).
Sassone-Corsi, P., Fromental, C. & Chambon, P. Oncogene Res. (submitted).
Borrelli, E., Hen, R. & Chambon, P. Nature 312, 608–612 (1984).
Velcich, A. & Ziff, E. Cell 42, 705–716 (1985).
Imperiale, M. J., Kao, H. T., Feldman, L. T., Nevins, J. R. & Strickland, S. Molec. cell. Biol. 4, 867–874 (1984).
Borrelli, E. et al. Proc. natn. Acad. Sci. U.S.A. 83, 2846–2849 (1986).
Nir, U., Walkeer, M. D. & Rutter, W. J. Proc. natn. Acad. Sci. U.S.A. 83, 3180–3184 (1986).
Goodbourn, S., Burstein, H. & Maniatis, T. Cell 45, 601–610 (1986).
Zinn, K., Dimaio, D. & Maniatis, T. Cell 34, 865–879 (1983).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sassone-Corsi, P., Verma, I. Modulation of c-"os gene transcription by negative and positive cellular factors. Nature 326, 507–510 (1987). https://doi.org/10.1038/326507a0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/326507a0
This article is cited by
-
Critical role for NF-κB-induced JunB in VEGF regulation and tumor angiogenesis
The EMBO Journal (2007)
-
Re-expression of SPR1 in Breast Cancer Cells by Phorbol 12-Myristate 13-Acetate (PMA) or UV Irradiation Is Mediated by the AP-1 Binding Site in the SPR1 Promoter
Molecular Medicine (1999)
-
Regulation of HSP60 mRNA expression in a human ovarian carcinoma cell line
Cancer Chemotherapy and Pharmacology (1993)
-
Molecular mechanisms of tubulointerstitial hypertrophy and hyperplasia
Kidney International (1991)
-
Negative regulation of serum-responsive enhancer elements
Nature (1989)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
