Abstract
The microsporidia are a group of unusual, obligately parasitic protists that infect a great variety of other eukaryotes, including vertebrates, arthropods, molluscs, annelids, nematodes, cnidaria and even various ciliates, myxosporidia and gregarines1. They possess a number of unusual cytological and molecular characteristics. Their nuclear division is considered to be primitive2, they have no mitochondria3, their ribosomes and ribosomal RNAs are reported to be of prokaryotic size4,5 and their large ribosomal subunit contains no 5.8S rRNA6. The uniqueness of the microsporidia may reflect their phylogenetic position, because comparative sequence analysis shows that the small subunit rRNA of the microsporidium Vairimorpha necatrix7,8 is more unlike those of other eukaryotes than any known eukaryote 18S rRNA sequence. We conclude that the lineage leading to microsporidia branched very early from that leading to other eukaryotes.
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References
Sprague, V. in Comparative Pathobiology Vol. 2 (eds Bulla, L. A. & Cheng, T. C.) 335–385 (Plenum, New York, 1977).
Raikov, I. B. The Protozoan Nucleus: Morphology and Evolution, 124–129 (Springer, Berlin, 1982).
Vavra, J. in Comparative Pathobiology Vol. 1 (eds Bulla, L. A. & Cheng, T. C.) 1–86 (Plenum, New York, 1976).
Ishihara, R. & Hayashi, Y. J. invert. Pathobiol. 11, 377–385 (1968).
Curgy, J. J., Vavra, J. & Vivares, C. Biol. Cellulaire 38, 49–52 (1980).
Vossbrinck, C. R. & Woese, C. R. Nature 320, 287–288 (1986).
Krammer, J. P. Invert. Pathol. 7, 117–121 (1965).
Maddox, J. V. & Sprenkel, R. K. Misc. Publs ent. Soc. Am. 11, 65–84 (1978).
Taylor, F. J. R. BioSystems 10, 67–89 (1978).
Cavalier-Smith, T. BioSystems 14, 461–481 (1981).
Lee, J. J., Hutner, S. H. & Bovee, E. C. An Illustrated Guide to the Protozoa (Society of Protozoologists, Lawrence, Kansas, 1985).
Margulis, L. Symbiosis in Cell Evolution (Freeman, San Francisco, 1981).
Woese, C. R. & Fox, G. E. Proc. natn. Acad. Sci. U.S.A. 74, 5088–5090 (1977).
Fox, G. E. et al. Science 209, 457–464 (1980).
Sogin, M. L., Elwood, H. J. & Gunderson, J. H. Proc. natn. Acad. Sci. U.S.A. 83, 1383–1387 (1986).
Balbiani, E. G. C.r. hebd. Acad. Sci., Paris 95, 1168–1171 (1882).
Wenyon, C. M. Protozoology (Bailliere, Tindall and Cox, London, 1926).
Vavra, J. Proc. First Int. Congr. Parasitol, 443–444 (1964).
Corliss, J. O. & Levine, M. D. J. Protozool. 10 (suppl.), 26–27 (1963).
Rubtsov, P. M. et al. Nucleic Acids Res. 8, 5779–5793 (1980).
Brosius, J., Palmer, J. L., Kennedy, J. P. & Noller, H. F. Proc. natn. Acad. Sci. U.S.A. 75, 4801–4805 (1978).
Woese, C. R., Gutell, R. R., Gupta, R. & Noller, H. F. Microbiol. Rev. 47, 621–669 (1983).
Gutell, R. R., Weiser, B., Woese, C. R. & Noller, H. F. Prog. nucleic Acid Res. 32, 155–216 (1985).
Qu, L. H., Michot, B. & Bachellerie, J. P. Nucleic Acids Res. 11, 5903–5920 (1983).
Lane, D. et al. Proc. natn. Acad. Sci. U.S.A 82, 6955–6959 (1985).
De Soete, G. Psychometrika 48, 621–626 (1983).
De Soete, G. Z. Naturforsch. 38, 156–158 (1983).
SwoBord, D. PAUP Users Manual Version 2.3 (Natural History Survey, Champaign Illinois, 1985).
Walker, C. G. et al. in Earth's Earliest Biosphere (ed. Schopf, J. W.) 260–289 (Princeton University Press, Princeton, 1983).
McCarroll, R. et al. Biochemistry 22, 5858–5868 (1983).
Sogin, M. & Elwood, H. J. J. molec. Evol. 23, 53–60 (1986).
Messing, J., Carlson, J., Hagen, G., Rubenstein, I. & Oleson, A. DNA 3, 31–40 (1984).
Salim, M. & Maden, E. H. Nature 291, 205–208 (1981).
Olsen, G. J. et al. J. molec. Evol. 22, 301–307 (1985).
Jukes, T. H. & Cantor, C. R. in Mammalian Protein Metabolism (ed. Munro, H. N.) 21–132 (Academic, New York, 1969).
Loenen, W. A. M. & Brammar, W. J. Gene 20, 249–259 (1980).
Messing, J. Meth. Enzym. 101, 20–78 (1983).
Biggin, M. D., Gibson, T. J. & Hong, G. F. Proc. natn. Acad. Sci. U.S.A 80, 3963–3965 (1983).
Mills, D. R. & Kramer, F. R. Proc. natn. Acad. Sci. U.S.A. 76, 2232–2235 (1979).
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Vossbrinck, C., Maddox, J., Friedman, S. et al. Ribosomal RNA sequence suggests microsporidia are extremely ancient eukaryotes. Nature 326, 411–414 (1987). https://doi.org/10.1038/326411a0
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DOI: https://doi.org/10.1038/326411a0
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