Support for multistage models of oncogenesis has been provided by several highly leukaemogenic retrovirus isolates that have transduced more than one host cell gene1–5. Where functional studies have been performed, these retroviral oncogenes show synergy for in vitro transformation and leukaemogenesis6,7. In naturally occurring feline leukaemias associated with feline leukaemia virus (FeLV), retroviral transduction of myc is a frequent oncogenic mechanism8–10. But evidence suggesting that the FeLV v-myc genes might be insufficient for leukaemogenesis was provided by the latency (12 weeks) and clonality of FeLV/v-myc-induced tumours and the absence of demonstrable in vitro transformation by these viruses11. In the search for secondary leukaemogenic events in FeLV/v-myc tumours, we have identified a case of FeLV transduction of a T-cell antigen receptor β-chain gene. The proviruses carrying this gene (which we have named v-tcr) were a separate population from those carrying v-myc. In its normal role, the T-cell receptor β-chain forms part of a multimeric complex involved in antigen recognition12–14 and T-cell activation15,16. We suggest that v-tcr is a novel viral oncogene which assisted v-myc in the genesis of a naturally occurring case of thymic lymphosarcoma.
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Vennstrom, B. & Bishop, J. M. Cell 28, 135–143 (1982).
Jansen, H. W., Ruckert, B., Lurz, R. & Bister, K. EMBO J. 2, 1969–1975 (1983).
Kan, N. C., Flordellis, C. S., Mark, G. E., Duesberg, P. H. & Papas, T. S. Proc. natn. Acad. Sci. U.S.A. 81, 3000–3004 (1984).
Nunn, M. F., Seeburg, P. H., Moscovici, C. & Duesberg, P. H. Nature 306, 395–397 (1983).
Leprince, D. et al. Nature 306, 391–394 (1983).
Frykberg, L. et al. Cell 32, 227–238 (1983).
Graf, T. et al. Cell 45, 357–364 (1986).
Neil, J. C. et al. Nature 308, 814–820 (1984).
Levy, L. S., Gardner, M. B. & Casey, J. W. Nature 308, 853–856 (1984).
Mullins, J. I., Brody, D. S., Binari, R. C. Jr & Cotter, S. M. Nature 308, 856–858 (1984).
Onions, D., Lees, G., Forrest, D. & Neil, J. C. Int. J. Cancer (in the press).
Meuer, S. C. et al. Nature 303, 808–810 (1983).
Dembic, Z. et al. Nature 320, 232–238 (1986).
Yague, J. et al. Cell 42, 81–87 (1985).
Samuelson, L. E., Harford, J. B. & Klausner, R. D. Cell 43, 223–231 (1985).
Imboden, J. B., Weiss, A. & Stobo, J. D. Immun. Today 6, 328–331 (1985).
Royer, H. D. Cell 39, 261–266 (1984).
Raulet, D. H., Garman, R. D., Saito, H. & Tonegawa, S. Nature 314, 103–106 (1985).
Collins, M. K. L. et al. Proc. natn. Acad. Sci. U.S.A. 82, 4503–4507 (1985).
Stewart, M. et al. Virology 154, 121–134 (1986).
Stewart, M. et al. J. Virol. 58, 825–834 (1986).
Doggett, D. L. et al. J. Virol. (submitted).
Besmer, P. et al. Nature 308, 415–421 (1986).
Malissen, M. et al. Cell 37, 1101–1110 (1984).
Gascoigne, N. R. J., Chien, Y., Becker, D. M., Kavaler, J. & Davis, M. M. Nature 310, 387–391 (1984).
Herr, W. J. Virol. 49, 471–478 (1984).
Barth, R. K. et al. Nature 316, 517–523 (1985).
Schiffer, M., Wu, T. T. & Kabat, E. A. Proc. natn. Acad. Sci. U.S.A. 83, 4461–4463 (1986).
Belhke, M. A. et al. Science 229, 566–570 (1985).
Leiden, J. M. & Strominger, J. L. Proc. natn. Acad. Sci. U.S.A. 83, 4456–4460 (1986).
Hedrick, S. M., Nielsen, E. A., Kavaler, J., Cohen, D. I. & Davis, M. M. Nature 308, 153–158 (1984).
Goverman, J. et al. Cell 40, 859–867 (1985).
Yanagi, Y. et al. Nature 308, 145–149 (1984).
Bargmann, C. I., Hung, M-C. & Weinberg, R. A. Cell 45, 649–657 (1986).
Krissansen, G. W., Owen, M. J., Verbi, W. & Crumpton, M. J. EMBO J. 5, 1799–1808 (1986).
Gold, D. et al. Nature 321, 431–434 (1986).
Tunnacliffe, A., Sims, J. E. & Rabbitts, T. H. EMBO J. 5, 1245–1252 (1986).
Chien, Y-H. et al. Nature 312, 31–35 (1984).
Saito, H. et al. Nature 312, 36–40 (1986).
Meuer, S. C. et al. Proc. natn. Acad. Sci. U.S.A. 81, 1509–1513 (1984).
Rapp, U. R., Cleveland, J. L., Brightman, K., Scott, A. & Ihle, J. N. Nature 317, 434–438 (1985).
Mullins, J. I., Casey, J. W., Nicolson, M. O., Burck, K. B. & Davidson, N. in Proceedings of the Third International FeLV Symposium (eds Hardy, W. D. Jr, Essex, M. & McClelland, A. J.) 373–380 (Elsevier, New York, 1980).
Casey, J. W. et al. Proc. natn. Acad. Sci. U.S.A. 77, 7778–7782 (1981).
Norrander, J., Kempe, T. & Messing, J. Gene 26, 101–106 (1983).
Sanger, F., Coulson, A. R., Barrell, B. G., Smith, A. J. H. & Roe, B. J. molec. Biol. 143, 161–178 (1980).
Rights and permissions
About this article
Cite this article
Fulton, R., Forrest, D., McFarlane, R. et al. Retroviral transduction of T-cell antigen receptor β-chain and myc genes. Nature 326, 190–194 (1987). https://doi.org/10.1038/326190a0
This article is cited by
Polymerase chain reaction-based detection of myc transduction in feline leukemia virus-infected cats
Archives of Virology (2018)
AKT capture by feline leukemia virus
Archives of Virology (2017)
Molecular cloning of feline leukemia provirus genomes integrated in the feline large granular lymphoma cells
Archives of Virology (1990)
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.