Abstract
The retrovirus that causes AIDS has revealed enough of its life history for a variety of therapeutic strategies to be apparent. Some of these are suitable for immediate application in clinical trials or have already yielded positive results in some patients.
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References
Gottlieb, M. S. et al. New Engl. J. Med. 305, 1425–1431 (1981).
Broder, S. & Gallo, R. C. New Engl. J. Med. 311, 1292–1297 (1984).
Gallo, R. C. et al. Science 224, 500–503 (1984).
Popovic, M., Sarngadharan, M. G., Read, E. & Gallo, R. C. Science 224, 497–500 (1984).
Barré-Sinoussi, F. et al. Science 220, 868–871 (1983).
Levi, J. A. et al. Science 225, 840–842 (1984).
Coffin, J. et al. Nature 321, 10 (1986).
Shaw, G. M. et al. Nature 227, 177–182 (1985).
Ho, D. D. et al. New Engl. J. Med. 313, 1493–1497 (1985).
Resniek, L. et al. New Engl. J. Med. 313, 1498–1504 (1985).
Gartner, S. et al. Science 233, 215–219 (1986).
Koenig, S. et al. Science 233, 1089–1093 (1986).
Mitsuya, H. et al. Proc. natn. Acad. Sci. U.S.A. 82, 7096–7100 (1985).
Yarchoan, R. et al. Lancet i, 575–580 (1986).
Mitsuya, H., Matsukura, M. & Broder, S. in AIDS: Modern Concepts and Therapeutic Challenges (ed. Broder, S.) 303–333 (Dekker, New York, 1987).
Gross, L. Oncogenic Viruses 3rd edn (Pergamon, Oxford, 1983).
Baltimore, D. Nature 226, 1209–1211 (1970).
Temin, H. & Mizutani, S. Nature 226, 1211–1213 (1970).
Toh, H., Hayashida, H. & Miyata, T. Nature 305, 827–829 (1983).
Ratner, L. et al. Nature 313, 277–284 (1985).
Wain-Hobson, S., Sonigo, P., Danos, O., Cole, S. & Alizon, M. Cell 40, 9–17 (1985).
Sodroski, J. et al. Science 227, 171–173 (1985).
Sodroski, J. et al. Nature 319, 555–559 (1986).
Sodroski, J. et al. Nature 321, 412–417 (1986).
Feinberg, M. B., Jarrett, R. F., Aldovini, A., Gallo, R. C. & Wong-Staal, F. Cell 46, 807–817 (1986).
Dalgleish, A. G. et al. Nature 312, 763–767 (1984).
Klatzmann, D. et al. Nature 312, 767–768 (1984).
Pert, C. B. et al. Proc. natn. Acad. Sci. U.S.A. 83, 9254–9258 (1986).
Sodroski, J., Goh, W. C., Rosen, C., Campbell, K. & Haseltine, W. A. Nature 322, 470–474 (1986).
Lifson, J. D. et al. Nature 323, 725–728 (1986).
Fisher, A. G. et al. Science 233, 655–659 (1986).
Matsushita, S. et al. Proc. natn. Acad. Sci. U.S.A. 83, 2672–2676 (1986).
Veronese, F. D. et al. Science 231, 1289–1291 (1986).
Tanese, N., Sodroski, J., Haseltine, W. A. & Goff, S. P. J. Virol. 59, 743–745 (1986).
Mitsuya, H. et al. Science 226, 172–174 (1984).
Broder, S. et al. Lancet ii, 627–630 (1985).
Rosenbaum, W. et al. Lancet i, 450–451 (1985).
Sandstrom, E. G., Kaplan, J. C., Byington, R. E. & Hirsch, M. S. Lancet i, 1480–1481 (1985).
Cullen, B. R. Cell 46, 973–982 (1986).
Okamoto, T. & Wong-Staal, R. Cell 47, 29–35 (1986).
McCormick, J. B., Getchell, J. P., Mitchell, S. W. & Hicks, D. R. Lancet ii, 1367–1369 (1984).
Zamecnik, P. C., Goodchild, J., Taguchi, Y. & Sarin, P. Proc. natn. Acad. Sci. U.S.A. 83, 4143–4146 (1986).
Henderson, L. E., Krutzsch, H. C. & Oroszlan, S. Proc. natn. Acad. Sci. U.S.A. 80, 339–343 (1983).
Schultz, A. M. & Oroszlan, S. J. Virol. 46, 355–361 (1983).
Ho, D. D. et al. Lancet i, 602–604 (1985).
Mitsuya, H. & Broder, S. Proc. natn. Acad. Sci. U.S.A. 83, 1911–1915 (1986).
Robins, M. J. & Robins, R. K. J. Am. chem. Soc. 86, 3585–3586 (1964).
Horwitz, J. P., Chua, J. & Noel, M. J. org. Chem. 29, 2076–2078 (1964).
Doering, A. M., Janse, M. & Cohen, S. S. J. bact. 92, 565–574 (1966).
Horwitz, J. P., Chua, J., Noel, M. & Donatti, J. T. J. org. Chem. 32, 817–818 (1967).
Atkinson, M. R., Deutscher, M. P., Kornberg, A., Ruseel, A. F. & Moffat, J. G. Biochemistry 8, 4897–4904 (1969).
Toji, L. & Cohen, S. S. J. Bact. 103, 323–328 (1970).
Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).
Cooney, D. A. et al. Biochem. Pharmac. 35, 2065–2068 (1986).
Mitsuya, H. et al. Proc. natn. Acad. Sci. U.S.A. (in the press).
Chi, I.-M. et al. Nature 317, 366–368 (1985).
Dahlberg, J. E., Mitsuya, H., Broder, S. & Aaronson, S.A. Proc. natn. Acad. Sci. U.S.A. (in the press).
Waqar, M. A., Evans, M. J., Manly, K. F., Hughs, R. G. & Huberman, J. A. J. cell Physiol. 121, 402–408 (1984).
Ostertag, W. et al. Proc. natn. Acad. Sci. U.S.A. 71, 4980–4985 (1974).
Furman, P. A. et al. Proc. natn. Acad. Sci. U.S.A. 83, 8333–8337 (1986).
Yarchoan, R. et al. Lancet i, 132–135 (1987).
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Mitsuya, H., Broder, S. Strategies for antiviral therapy in AIDS. Nature 325, 773–778 (1987). https://doi.org/10.1038/325773a0
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DOI: https://doi.org/10.1038/325773a0
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