Abstract
In the search for new β-lactam antibiotics of natural origin, the discoveries of cephamycins1and sulfazecins2 (monobactams3) were important turning points in that they accelerated many screening efforts aimed at other new compounds. In our target-directed screening for β-lactam antibiotics using β-lactam hypersensitive mutants4,5, we have examined Gram-negative bacteria isolated from natural habitats and have recently reported several types of β-lactam antibiotics such as cephabacins6,7 and formadicins8. Here we report a novel antibiotic, lactivicin, found using this system. Although lactivicin has various biological activities commonly observed in β-lactam antibiotics, it does not possess a β-lactam ring in its molecule, but has the unique structure of a dicyclic dipeptide.
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References
Nagarajan, R. et al. J. Am. chem. Soc. 93, 2308–2310 (1971).
Iraada, A., Kitano, K., Kintaka, K., Muroi, M. & Asai, M. Nature 289, 590–591 (1981).
Sykes, R. B. et al. Nature 291, 489–491 (1982).
Nozaki, Y., Harada, S., Kitano, K. & Imada, A. J. Antibiot. 37, 218–226 (1984).
Kitano, K. et al. J. Ferment. Technol. 53, 327–338 (1975).
Ono, H., Nozaki, Y., Katayama, N. & Okazaki, H. J. Antibiot. 37, 1528–1535 (1985).
Nozaki, Y., Katayama, N., Tsubotani, S., Ono, H. & Okazaki, H. J. Antibiot. 38, 1141–1151 (1985).
Katayama, N. et al. J. Antibiot. 38, 1117–1127 (1985).
Harada, S., Tsubotani, S., Hida, T., Ono, H. & Okazaki, H. Tetrahedron Lett. (in the press).
Weeks, O. B. in Bergey's Manual of Determinative Bacteriology 8th edn (eds Buchanan, R. E. & Gibbons, N. E.) 357–364 (Williams & Wilkins, Baltimore, 1974).
Holmes, B. & Owen, R. J. Int. J. Syst. Bact. 29, 416–426 (1979).
Christensen, P. & Cook, F. D. Int. J. Syst. Bact. 28, 367–393 (1978).
Nozaki, Y. et al. J. Antibiot. 37, 1555–1565 (1984).
Neuhaus, F. C. in Antibiotics I (eds Gottlieb, D. & Shaw, P. D.) 40–83 (Springer, Berlin, 1967).
Waxman, D. J. & Strominger, J. L. A. Rev. Biochem. 52, 825–869 (1983).
Boyd, D. B., Elzey, T. K., Hatfield, L. D., Kinnick, M. D. & Morin, J. M. Jr Tetrahedron Lett. 27, 3453–3456 (1986).
Boyd, D. B. et al. Tetrahedron Lett. 27, 3457–3460 (1986).
Baldwin, J. E., Lowe, C., Schofield, C. J. & Lee, E. Tetrahedron Lett. 27, 3461–3464 (1986).
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Nozaki, Y., Katayama, N., Ono, H. et al. Binding of a non-β-lactam antibiotic to penicillin-binding proteins. Nature 325, 179–180 (1987). https://doi.org/10.1038/325179a0
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DOI: https://doi.org/10.1038/325179a0
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