Abstract
It has been shown that the entry of the malaria parasite into the red blood cell requires the presence of ATP in the host cell cytoplasm1,2. In red blood cell ghosts that contain no ATP the receptor on the extracellular surface remains in place and parasites will bind to the membrane, but will not enter3. ATP is thus necessary for one of the steps4 in the invasion sequence that follows recognition and attachment. The process of entry appears to involve the active participation of the host cell membrane cytoskeleton5. We have suggested2 that the function of the intracellular ATP may be to regulate phosphorylation of the cytoskeleton. We now present evidence that the activity of the membrane-associated cyclic AMP-independent kinase of the red blood cell is inseparable from invasion; the active substrate may be spectrin.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Olson, J. A. & Kilejian, A. J. Cell Biol. 95, 757–762 (1982).
Dluzewski, A. R., Rangachari, K., Wilson, R. J. M. & Gratzer, W. B. Molec. biochem. Parasitol. 9, 145–160 (1983).
Miller, L. H. Bull. WHO 55, 157–162 (1977).
Aikawa, M., Miller, L. H., Johnson, J. & Rabbege, J. J. Cell Biol. 77, 72–82 (1978).
Dluzewski, A. R., Rangachari, K., Wilson, R. J. M. & Gratzer, W. B. Br. J. Haematol. 55, 629–637 (1983).
Harris, H. W. & Lux, S. E. J. biol. Chem. 255, 11512–11520 (1980).
Birchmeier, W. & Singer, S. J. J. Cell Boil. 73, 647–659 (1977).
Anderson, J. & Tyler, J. M. J. biol. Chem. 255, 1259–1265 (1980).
Patel, V. P. & Fairbanks, G. J. Cell Biol. 88, 430–449 (1981).
Loyter, A. A., Ben-Zaquen, R., Marash, R. & Milner, Y. Biochemistry 16, 3903–3909 (1977).
Nelson, M. J. & Huestis, W. H. Biochim. biophys. Acta 600, 398–405 (1980).
Lalazar, A. & Loyter, A. Proc. natn. Acad. Sci. U.S.A. 76, 318–321 (1979).
McLaren, D. J., Bannister, L. H., Trigg, P. I. & Butcher, G. A. Parasitology 79, 125–139 (1979).
Dluzewski, A. R., Rangachari, K., Wilson, R. J. M. & Gratzer, W. B. Br. J. Haematol. 49, 97–101 (1981).
Hosey, M. M. & Tao, M. Biochim. biophys. Acta 482, 348–357 (1977).
Tao, M., Conway, R. & Cheta, S. J. biol. Chem. 255, 2563–2568 (1980).
Trager, W. & Jensen, J. B. Science 193, 673–675 (1976).
Dluzewski, A. R., Ling, I. T., Rangachari, K., Bates, P. & Wilson, R. J. M. Trans. R. Soc. trop. Med. Hyg. 78, 622–637 (1984).
Bradford, M. M. Analyt. Biochem. 72, 248–254 (1976).
Pinder, J. C., Dhermy, D., Baines, A. J., Lux, S. E. & Gratzer, W. B. Br. J. Haematol. 56, 455–463 (1983).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rangachari, K., Dluzewski, A., Wilson, R. et al. Control of malarial invasion by phosphorylation of the host cell membrane cytoskeleton. Nature 324, 364–365 (1986). https://doi.org/10.1038/324364a0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/324364a0
This article is cited by
-
In vitro delayed response to dihydroartemisinin of malaria parasites infecting sickle cell erythocytes
Malaria Journal (2024)
-
An external sensing system in Plasmodium falciparum-infected erythrocytes
Malaria Journal (2016)
-
Quantitative phospho-proteomics reveals the Plasmodium merozoite triggers pre-invasion host kinase modification of the red cell cytoskeleton
Scientific Reports (2016)
-
Phenotypic and transcriptomic analyses of Plasmodium falciparum protein kinase A catalytic subunit inhibition
Parasitology Research (2009)
-
Role of calcium and erythrocyte cytoskeleton phosphorylation in the invasion ofPlasmodium falciparum
Parasitology Research (1990)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.