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Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

Nature volume 321, pages 406411 (22 May 1986) | Download Citation

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Abstract

Distinct classes of acetylcholine receptor channels are formed when Xenopus oocytes are injected with combinations of the bovine α-, β-, γ- and δ- or the α-, β-, γ- and ε-subunit-specific messenger RNAs. The conductance and gating properties of the two classes of channels, in conjunction with the developmental changes in the muscular contents of the mRNAs, suggest that replacement of the γ-subunit by the ε-subunit is responsible for the functional alteration of the receptor during muscle development.

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Affiliations

  1. Departments of Medical Chemistry and Molecular Genetics, Kyoto University Faculty of Medicine, Kyoto 606, Japan

    • Masayoshi Mishina
    • , Toshiyuki Takai
    • , Keiji Imoto
    • , Masaharu Noda
    • , Tomoyuki Takahashi
    •  & Shosaku Numa
  2. Department of Physiology, Kyoto University Faculty of Medicine, Kyoto 606, Japan

    • Tomoyuki Takahashi
  3. Max-Planck-Institut für biophysikalische Chemie, D-3400 Göttingen, FRG

    • Christoph Methfessel
    •  & Bert Sakmann

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https://doi.org/10.1038/321406a0

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