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Splice-site selection by a self-splicing RNA of Tetrahymena

Nature volume 321, pages 133139 (08 May 1986) | Download Citation

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Abstract

5′ Splice-site selection by the self-splicing Tetrahymena ribosomal RNA precursor requires the formation of a particular RNA helix by base pairing between an intron ‘guide sequence’ and bases surrounding the 5′ splice junction. Part of the guide sequence subsequently holds and positions the 3′ end of the cut 5′ exon to attack the 3′ splice junction.

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Affiliations

  1. Department of Biochemistry and Applied Molecular Biology, University of Manchester Institute of Science and Technology, PO Box 88, Manchester M60 1QD, UK

    • Richard B. Waring
    • , Paul Towner
    • , Stephen J. Minter
    •  & R. Wayne Davies
  2. Allelix Inc., 6850 Goreway Drive, Mississauga, Ontario, Canada L4V 1P1

    • Stephen J. Minter
    •  & R. Wayne Davies
  3. Present address: Department of Pharmacology, UMDNJ, Rutgers College of Medicine, PO Box 101, Piscataway, New Jersey 08854, USA.

    • Richard B. Waring

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https://doi.org/10.1038/321133a0

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