Abstract
Activity-induced changes in the efficacy of synaptic transmission between neurones are central to several prominent theories of learning1–4. In both in vivo and in vitro preparations of the hippocampus, a conditioning high-frequency stimulus delivered to afferent fibres results in a long-term potentiation of synaptic transmission at those inputs5–8. Evidence has been provided supporting both presynaptic5,9–11 and postsynaptic12–14 sites as loci where critical events occur in the development of potentiation. In this study we report that long-term potentiation is reversibly blocked by intracellular injection of hyperpolarizing current in the postsynaptic cell during the conditioning high-frequency stimulus, suggesting the involvement of a voltage-dependent postsynaptic mechanism.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hebb, D. O. Organization of Behavior (Wiley, New York, 1949).
Marr, D. J. Physiol., Lond. 202, 437–470 (1969).
Albus, J. S. Math. Biosci. 10, 25–61 (1971).
Stent, G. S. Proc. natn. Acad. Sci. U.S.A. 70, 997–1001 (1973).
Bliss, T. V. P. & L∅mo, T. J. Physiol., Lond. 232, 331–356 (1973).
Bliss, T. V. P. & Gardner-Medwin, A.R. J. Physiol., Lond. 232, 357–374 (1973).
Schwartzkroin, P. A. & Wester, K. Brain Res. 89, 107–119 (1975).
Andersen, P., Sundberg, S. H., Sveen, O. & Wigström, H. Nature 266, 736–737 (1977).
Dolphin, A. C., Errington, M. L. & Bliss, T. V. P. Nature 297, 496–498 (1982).
Andersen, P., Sundberg, S. H., Sveen, O., Swan, S. W. & Wigström, H. J. Physiol., Lond. 302, 463–482 (1980).
McNaughton, B. L., Douglas, R. M. & Goddard, G. V. Brain Res. 157, 277–293 (1978).
Lynch, G., Larson, J., Kelso, S., Barrionuevo, G. & Schottler, F. Nature 305, 719–721 (1983).
Dunwiddie, T. & Lynch, G. J. Physiol., Lond. 276, 353–367 (1978).
Baudry, M., Bundman, M. C., Smith, E. K. & Lynch, G. Science 212, 937–938 (1981).
Nicoll, R. A. & Alger, B. E. J. Neurosci. Meth. 4, 153–156 (1981).
Alger, B. E. & Nicoll, R. A. J. Physiol., Lond. 328, 105–123 (1982).
Barrionuevo, G. & Brown, T. H. Proc. natn. Acad. Sci. U.S.A. 80, 7347–7351 (1983).
Barrionuevo, G. & Brown, T. H. Soc. Neurosci. Abstr. 10, 78 (1984).
Wigström, H., McNaughton, B. L. & Barnes, C. A. Brain Res. 233, 195–199 (1982).
Ramón y Cajal, S. Histologie du système nerveux de l' Homme et des Vertébrés (Maloine, Paris, 1911).
Swanson, L. W., Wyss, J. M. & Cowan, W. M. J. comp. Neurol. 181, 681–716 (1978).
Brown, T. H. & Johnston, D. J. Neurophysiol. 50, 487–507 (1983).
Kelso, S. R. & Brown, T. H. Soc. Neurosci. Abstr. 11, 780 (1985).
Douglas, R. M., Goddard, G. V. & Riives, M. Brain Res. 240, 259–272 (1982).
Wigström, H. & Gustafsson, B. Nature 301, 603–604 (1983).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Malinow, R., Miller, J. Postsynaptic hyperpolarization during conditioning reversibly blocks induction of long-term potentiation. Nature 320, 529–530 (1986). https://doi.org/10.1038/320529a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/320529a0
This article is cited by
-
A dedicated hypothalamic oxytocin circuit controls aversive social learning
Nature (2024)
-
Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses
Nature Communications (2021)
-
Chemogenetic Inactivation of Ventral Hippocampal Glutamatergic Neurons Disrupts Consolidation of Contextual Fear Memory
Neuropsychopharmacology (2014)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
