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DNA bending at adenine · thymine tracts

Abstract

Intrinsic bending of DNA molecules results from local structural polymorphism in regions of homopolymeric dA · dT which are at least 4 base pairs long; the A · T tracts must be repeated in phase with the helix screw. Bending, in the direction of base-pair tilt rather than roll, occurs at the junctions between the A · T tract and adjacent B-DNA, with a larger angle at the 3′ than at the 5′ end of the A tract.

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References

  1. Englund, P. T., Hajduk, S. L. & Marini, J. C. A. Rev. Biochem. 51, 695–726 (1982).

    Article  CAS  Google Scholar 

  2. Marini, J. C., Levene, S. D., Crothers, D. M. & Englund, P. T. Proc. natn. Acad. Sci. U.S.A. 79,7664–7668 (1982).

    Article  ADS  CAS  Google Scholar 

  3. Levene, S. D. & Crothers, D. M. J. biomolec. Struct. Dyn. 1, 429–435 (1983).

    Article  CAS  Google Scholar 

  4. Marini, J. C. et al. J. biol. Chem. 259, 8974–8979 (1984).

    CAS  PubMed  Google Scholar 

  5. Ntambi, J. M. et al. Molec. Biochem. Parasit. 12, 273–286 (1984).

    Article  CAS  Google Scholar 

  6. Wu, H. M. & Crothers, D. M. Nature 308, 509–513 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Hagerman, P. J. Proc. natn. Acad. Sci. U.S.A. 81, 4632–4636 (1984).

    Article  ADS  CAS  Google Scholar 

  8. Zahn, K. & Blattner, F. R. Nature 317, 451–453 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  9. Lerman, L. S. & Frisch, H. L. Biopolymers 21, 995–997 (1982).

    Article  CAS  PubMed  Google Scholar 

  10. Lumpkin, O. J. & Zimm, B. H. Biopolymers 21, 2315–2316 (1982).

    Article  CAS  PubMed  Google Scholar 

  11. Peck, L. C. & Wang, J. C. Nature 292, 375–378 (1981).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. Rhodes, D. & Klug, A. Nature 292, 378–380 (1981).

    Article  ADS  CAS  PubMed  Google Scholar 

  13. Strauss, F., Gaillard, C. & Prunell, A. Eur. J. Biochem. 118, 215–222 (1981).

    Article  CAS  PubMed  Google Scholar 

  14. Levene, S. D., Wu, H. M. & Crothers, D. M. Biochemistry. (in the press)

  15. Selsing, E., Wells, R. D., Alden, C. J. & Arnott, S. J. biol. Chem. 254, 5417–5422 (1979).

    CAS  PubMed  Google Scholar 

  16. Wu, H. M. thesis, Yale Univ. (1982).

  17. Depew, R. E. & Wang, J. C. Proc. natn. Acad. Sci. U.S.A. 72, 4275–4279 (1975).

    Article  ADS  CAS  Google Scholar 

  18. Trifonov, E. N. & Sussman, J. L. Proc. natn. Acad. Sci. U.S.A. 77, 3816–3820 (1980).

    Article  ADS  CAS  Google Scholar 

  19. Trifonov, E. N. Nucleic Acids Res. 8, 4041–4053 (1980).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Drew, H. R. et al. Proc. natn. Acad. sci. U.S.A. 78 2179–2183 (1981).

    Article  ADS  CAS  Google Scholar 

  21. Calladine, C. R. J.molec. Biol. 161, 343–352 (1982).

    Article  CAS  PubMed  Google Scholar 

  22. Dickerson, R. E. J.molec. Biol. 166 419–441 (1983).

    Article  CAS  PubMed  Google Scholar 

  23. Zhurkin, V. B., Lysov, Y. P. & Ivanov, V. I. Nucleic Acids Res. 6, 1081–1096 (1979).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Zhurkin, V. B. J. biomolec. Struct. Dyn. 2, 785–804 (1985).

    Article  CAS  Google Scholar 

  25. Arnott, S., Chandrasekaran, R., Hall, I. H. & Puigjaner, L. C. Nucleic Acids Res. 11, 4141–4155 (1983).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Thomas, G. A. & Peticolas, W. L. J. Am. chem. Soc. 105, 993–996 (1983).

    Article  CAS  Google Scholar 

  27. Jolles, B., Laigle, A., Chinsky, L. & Turpin, P. Y. Nucleic Acids Res. 13, 2075–2085 (1985).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Simpson, R. T. & Kunzler, P. Nucleic Acids Res. 6, 1387–1415 (1979).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Kunkel, G. R. & Martinson, H. G. Nucleic Acids Res. 9, 6869–6888 (1981).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Edmondson, S. P. & Johnson, W. C. Jr Biopolymers 24, 825–841 (1985).

    Article  CAS  PubMed  Google Scholar 

  31. Reynolds, V. L., Molineux, I. J., Kaplan, D. J., Swenson, D. H. & Hurley, L. H. Biochemistry 24, 6228–6237 (1985).

    Article  CAS  PubMed  Google Scholar 

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Koo, HS., Wu, HM. & Crothers, D. DNA bending at adenine · thymine tracts. Nature 320, 501–506 (1986). https://doi.org/10.1038/320501a0

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