Abstract
Both voltage-activated potassium channels1–4 and the concentration of free intracellular calcium5,6 have been implicated in the activation of T lymphocytes. Using the patch-clamp technique7, we now show an unexpected relationship between the level of intracellular calcium [Ca]i in human lymphocytes and the amplitude of a voltage-dependent current: the elevation of [Ca]i decreases the potassium conductance. This is in contrast to other systems where [Ca]i activates K+ channels. Our results suggest that the level of intracellular calcium regulates the effective number of K+ channels capable of being activated.
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Bregestovski, P., Redkozubov, A. & Alexeev, A. Elevation of intracellular calcium reduces voltage-dependent potassium conductance in human T cells. Nature 319, 776–778 (1986). https://doi.org/10.1038/319776a0
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DOI: https://doi.org/10.1038/319776a0
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