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A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

Nature volume 319, pages 743–748 (1986)Cite this article

Abstract

A biologically active complementary DNA clone of a transforming gene present in a human colon carcinoma contains gene sequences of both tropomyosin and a previously unknown protein tyrosine kinase. The predicted protein (641 amino acids) encoded by this oncogene seems to have been formed by a somatic rearrangement that replaced the extracellular domain of a putative transmembrane receptor by the first 221 amino acids of a non-muscle tropomyosin molecule.

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Authors and Affiliations

  1. Developmental Oncology Section, Basic Research Program, Frederick Cancer Research Facility, Frederick, Maryland, 21701, USA

    Dionisio Martin-Zanca & Mariano Barbacid

  2. Gene Expression Section, Basic Research Program, Frederick Cancer Research Facility, Frederick, Maryland, 21701, USA

    Stephen H. Hughes

Authors
  1. Dionisio Martin-Zanca
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  2. Stephen H. Hughes
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  3. Mariano Barbacid
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Martin-Zanca, D., Hughes, S. & Barbacid, M. A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature 319, 743–748 (1986). https://doi.org/10.1038/319743a0

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