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Post-transcriptional regulation accounts for the trans-activation of the human T-lymphotropic virus type III

Nature volume 319, pages 555–559 (1986)Cite this article

Abstract

The level of synthesis of viral proteins and heterologous proteins under the control of long terminal repeat sequences of human T-lymphotropic virus type HI (HTLV-III or LAV) increases dramatically in cells that constitutively express the HTLV-III trans-activator protein. Increased levels of protein synthesis occur without a comparable increase in the levels of corresponding messenger RNA. We propose that post-transcriptional events mediated by the HTLV-III trans-activator protein account for positive regulation of HTLV-III gene products in infected cells.

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Authors and Affiliations

  1. Department of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts, 01225, USA

    Craig A. Rosen, Joseph G. Sodroski, Wei Chun Goh, Andrew I. Dayton, Judith Lippke & William A. Haseltine

  2. Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts, 02115, USA

    William A. Haseltine

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  1. Craig A. Rosen
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  2. Joseph G. Sodroski
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  5. Judith Lippke
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Rosen, C., Sodroski, J., Goh, W. et al. Post-transcriptional regulation accounts for the trans-activation of the human T-lymphotropic virus type III. Nature 319, 555–559 (1986). https://doi.org/10.1038/319555a0

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