Abstract
In several cell types, messenger RNA levels of the nuclear proto-oncogene c-myb vary as a function of cellular proliferation ; a transient increase in c-myb steady-state mRNA, mediated by post-transcriptional mechanisms, occurs during cell-cycle progression. In contrast, both quiescent and proliferating immature thymocytes contain exceptionally high levels of c-myb mRNA as a consequence of increased c-myb transcription.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Heldin, C.-H. & Westermark, B. Cell 37, 9–20 (1984).
Pardee, A. B., Campisi, J. & Croy, R. G. in Cancer Cells Vol. 3 (eds Feramisco, J., Ozanne B. & Stiles, C.) 389–392 (Cold Spring Harbor Laboratory, New York, 1985).
Hartwell, L. H., Culotti, J., Pringle, J. & Reid, B. Science 183, 46–51 (1974).
Siminovitch, L. & Thompson, L. H. J. cell Physiol. 95, 361–366 (1978).
Leys, E. J. & Kellems, R. E. Molec. cell. Biol. 1, 961–971 (1981).
Farnham, P. J. & Schimke, R. T. J. biol. Chem. 260, 7675–7680 (1985).
Groudine, M. & Casimir, C. Nucleic Acids Res. 12, 1427–1446 (1984).
Thompson, C. B., Challoner, P. B., Neiman, P. E. & Groudine, M. Nature 314, 363–366 (1985).
Storms, R. et al. Molec. cell. Biol. 4, 2858–2864 (1984).
Eisenman, R. N., Tachibana, C. Y., Abrams, H. D. & Hann, S. Molec. cell. Biol. 5, 114–126 (1985).
Curran, T., Miller, A. D., Zokas, L. & Verma, I. M. Cell 36, 259–268 (1984).
Klempnauer, K.-H., Symonds, G., Evan, G. I. & Bishop, J. M. Cell 37, 537–547 (1984).
Boyle, W. J., Lampert, M. A., Lipsick, J. S. & Baluda, M. A. Proc. natn. Acad. Sci. U.S.A. 81, 4265–4269 (1984).
Kelly, K., Cochran, B. H., Stiles, C. D. & Leder, P. Cell 35, 603–610 (1983).
Greenberg, M. E. & Ziff, E. B. Nature 311, 433–438 (1984).
Muller, R., Bravo, R., Burckhardt, J. & Curran, T. Nature 312, 716–720 (1984).
Kruijer, W., Cooper, J. A., Hunter, T. & Verma, I. M. Nature 312, 711–716 (1984).
Muller, R., Curran, T., Muller, D. & Guilbert, L. Nature 314, 546–548 (1985).
Hann, S. R., Thompson, C. B. & Eisenman, R. N. Nature 314, 366–369 (1985).
Craig, R. W. & Bloch, A. Cancer Res. 44, 442–446 (1984).
Gonda, T. J., Sheiness, D. K. & Bishop, J. M. Molec. cell. Biol. 2, 617–624 (1982).
Westin, E. H. et al. Proc. natn. Acad. Sci. U.S.A. 79, 2194–2198 (1982).
Coll, J. et al. Expl. Cell Res. 149, 151–162 (1983).
Sheiness, D. & Gardinier, M. Molec. cell. Biol. 4, 1206–1212 (1984).
Gonda, T. J. & Metcalf, D. Nature 310, 249–251 (1984).
Chirgwin, J.M., Przbyla, A.E., MacDonald, R.J. & Rutter, W.J. Biochemistry 18, 5294–5299 (1979).
Perbal, B. & Baluda, M. A. J. Virol. 41, 250–257 (1982).
Dugaiczyk, A. et al. Biochemistry 22, 1605–1613 (1983).
Dani, C. et al. Proc. natn. Acad. Sci. U.S.A. 81, 7046–7050 (1984).
Stuart, P., Ito, M., Stewart, C. & Conrad, S. E. Molec. cell. Biol. 5, 1490–1497 (1985).
Nilsson, G., Belasco, J. G., Cohen, S. N. & von Gabain, A. Nature 312, 75–77 (1984).
Sittman, D. B., Graves, R. A. & Marzluff, W. F. Proc. natn. Acad. Sci. U.S.A. 80, 1849–1853 (1983).
Linial, M., Gunderson, N. & Groudine, M. Science 230, 1126–1132, 1985.
Krieg, P. A. & Melton, D. A. Nature 308, 203–206 (1984).
Groudine, M., Peretz, M. & Weintraub, H. Molec. cell. Biol. 1, 281–288 (1981).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Thompson, C., Challoner, P., Neiman, P. et al. Expression of the c-myb proto-oncogene during cellular proliferation. Nature 319, 374–380 (1986). https://doi.org/10.1038/319374a0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/319374a0
This article is cited by
-
From modulation of cellular plasticity to potentiation of therapeutic resistance: new and emerging roles of MYB transcription factors in human malignancies
Cancer and Metastasis Reviews (2023)
-
Proto-oncogenes in a eukaryotic unicellular organism play essential roles in plasmodial growth in host cells
BMC Genomics (2018)
-
Pseudomonas aeruginosa infection augments inflammation through miR-301b repression of c-Myb-mediated immune activation and infiltration
Nature Microbiology (2016)
-
MicroRNAs as regulatory elements in immune system logic
Nature Reviews Immunology (2016)
-
MYB function in normal and cancer cells
Nature Reviews Cancer (2008)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.