Abstract
Class I HLA (histocompatibility locus antigen) molecules are the targets of allospecific cytolytic T lymphocytes (CTL) in graft rejection, and constitute the restricting elements necessary for the interaction between antiviral CTL and virus-infected cells. Cells expressing only one HLA in the absence of other human molecules would provide a remarkable model for studying the function of these molecules. However, HLA+ murine cells transfected with human genes1–5 are generally not lysed by allospecific human CTL5–8, and this is ascribed to insufficient HLA expression, lack of human β2-microglobulin, alteration of HLA molecules or absence of receptors for human T8 or LFA1 molecules in murine cells6–8. Here we report, for the first time, the specific lysis of virus-infected HLA+ murine cells by HLA-restricted antiviral human CTL. Therefore, these murine cells constitute an excellent model for studying the role of HLA molecules.
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Gomard, E., Begue, B., Sodoyer, S. et al. Murine cells expressing an HLA molecule are specifically lysed by HLA-restricted antiviral human T cells. Nature 319, 153–154 (1986). https://doi.org/10.1038/319153a0
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DOI: https://doi.org/10.1038/319153a0
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