Abstract
The crystal structure of a complex between the DNA-binding domain of phage 434 repressor and a synthetic 434 operator shows that the protein, very similar in conformation to λ repressor, binds to B-form DNA with the second α-helix of a helix–turn–helix motif lying in the major groove.
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References
Pabo, C. O. & Lewis, M. Nature 298, 443–447 (1982).
Bushman, F. D., Anderson, J. E., Harrison, S. C. & Ptashne, M. Nature 316. 651–653 (1985).
Anderson, W. F., Ohlendorf, D. H., Takeda, Y. & Matthews, B. W. Nature 290, 754–758 (1981).
McKay, D. B. & Steitz, T. A. Nature 290, 744–749 (1981).
Steitz, T. A., Ohlendorf, D. H., McKay, D. B., Anderson, W. F. & Matthews, B. W. Proc. natn. Acad. Sci. U.S.A. 79, 3097–3100 (1982).
Sauer, R. T., Yocum, R. R., Doolittle, R. F., Lewis, M. & Pabo, C. O. Nature 298, 447–451 (1982).
Takeda, Y., Ohlendorf, D. H., Anderson, W. F. & Matthews, B. W. Science 221, 1020–1026 (1983).
Ohlendorf, D. H., Anderson, W. F., Fisher, R. G., Takeda, Y. & Matthews, B. W. Nature 298, 718–723 (1982).
Weber, I. T. & Steitz, T. A. Proc. natn. Acad. Sci. U.S.A. 81, 3973–3977 (1984).
Ebright, R. H., Cessart, P., Gicquel-Sanzey, B. & Beckwith, J. Proc. natn. Acad. Sci. U.S.A. 81, 7274–7278.
Wharton, R. P., Brown, E. L. & Ptashne, M. Cell 38, 361–369 (1984).
Wharton, R. P. & Ptashne, M. Nature 316, 601–605 (1985).
Anderson, J., Ptashne, M. & Harrison, S. C. Proc. natn. Acad. Sci. U.S.A. 81, 1307–1311 (1984).
Durbin, R. et al. Science (submitted).
Dickerson, R. E., Weinzierl, J. E. & Palmer, R. E. Acta crystallogr. B24, 997–1003 (1968).
Jones, T. A. J. appl. Crystallogr. 11, 268–272 (1978).
Bricogne, G. Acta crystallogr. A30, 395–405 (1974).
Bricogne, G. Acta crystallogr. A32, 832–847 (1976).
Hoi, W. G. J., van Duijnen, P. T. & Berendsen, H. J. C. Nature 273, 443–446 (1978).
Ohlendorf, D. H., Anderson, W. F., Lewis, M., Pabo, C. O. & Matthews, B. W. J. molec. Biol. 169, 757–769 (1983).
Crick, F. H. C. Acta crystallogr. 6, 685–689 (1953).
Lewis, M. et al. Cold Spring Harb. Symp. quant. Biol. 47, 435–440 (1983).
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Anderson, J., Ptashne, M. & Harrison, S. A phage repressor–operator complex at 7 Å resolution. Nature 316, 596–601 (1985). https://doi.org/10.1038/316596a0
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DOI: https://doi.org/10.1038/316596a0
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