Abstract
We describe a new class of drugs that selectively block serotonin M-receptors on peripheral neurones. Because of their high affinity, some of these drugs are the most potent of any pharmacological class yet reported. They have allowed the identification of three M-receptor subtypes, one of which is responsible for mediating the painful effects of serotonin in humans.
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Richardson, B., Engel, G., Donatsch, P. et al. Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs. Nature 316, 126–131 (1985). https://doi.org/10.1038/316126a0
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DOI: https://doi.org/10.1038/316126a0
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