Abstract
T lymphocytes involved in the cellular immune response carry cell-surface receptors, responsible for antigen and self recognition. This T-cell receptor molecule is a heterodimeric protein consisting of disulphide-linked α- and β-chains with variable (V) and constant (C) regions1–5. Several complementary DNA and genomic DNA clones have been isolated and characterized6–12. These analyses showed that the genomic arrangement and rearrangement of T-cell receptor genes using VT, diversity (DT), joining (JT) and CT gene segments is very similar to the structure of the known immunoglobulin genes (see ref. 13 for review). We have isolated two cDNA clones from an allospecific cytotoxic T cell, one of which shows a productive Vβ–Jβ–Cβ 1 rearrangement without an intervening Dβ segment. This Vβ gene segment is identical to the Vβ gene expressed in a helper T-cell clone specific for chicken red blood cells and H–2Ib (ref. 14). The other clone carries the Cβ2 gene of the T-cell receptor, but the Cβ2 sequence is preceded by a DNA sequence that does not show any similarity to Vβ or Jβ sequences.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Acuto, O. et al. Cell 34, 717–726 (1983).
Kappler, J., Kubo, R., Haskins, K., White, J. & Marrack, P. Cell 34, 727–737 (1983).
McIntyre, B. W. & Allison, J. P. Cell 34, 739–746 (1983).
Haskins, K. et al. J. exp. Med. 157, 1149–1169 (1983).
Meuer, S. C. et al. J. exp. Med. 157, 705–719 (1983).
Hedrick, S. M., Cohen, D. I., Nielsen, E. A. & Davis, M. M. Nature 308, 149–158 (1984).
Yanagi, Y. et al. Nature 308, 145–149 (1984).
Chien, Y., Gascoigne, N. R. J., Kavaler, J., Lee, N. E. & Davis, M. M. Nature 309, 322–326 (1984).
Siu, G. et al. Cell 37, 393–401 (1984).
Malissen, M. et al. Cell 37, 1101–1110 (1984).
Gascoigne, N. R. J., Chien, Y., Becker, D. M., Kavaler, J. & Davis, M. M. Nature 310, 387–391 (1984).
Siu, G. et al. Nature 311, 344–350 (1984).
Joho, R., Nottenberg, C., Coffman, R. L. & Weissman, I. L. Curr. Topics dev. Biol. 18, 15–58 (1983).
Patten, P. et al. Nature 312, 40–46 (1984).
Acha-Orbea, H., Zinkernagel, R. M. & Hengartner, M. Eur. J. Immun. 15, 31–36 (1985).
Yoshikai, Y. et al. Nature 312, 521–524 (1984).
Kranz, D. M. et al. Nature 313, 752–755 (1985).
Maniatis, T., Fritsch, E. F. & Sambrook, J. Molecular Cloning, A Laboratory Manual (Cold Spring Harbor Laboratory, New York, 1982).
Young, R. A. & Davis, R. W. Proc. natn. Acad. Sci. U.S.A. 80, 1194–1198 (1983).
Dente, L., Cesareni, G. & Cortese, R. Nucleic Acids Res. 11, 1645–1653 (1983).
Maxam, A. & Gilbert, W. Meth. Enzym. 65, 499–560 (1980).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rupp, F., Acha-Orbea, H., Hengartner, H. et al. Identical Vβ T-cell receptor genes used in alloreactive cytotoxic and antigen plus I–A specific helper T cells. Nature 315, 425–427 (1985). https://doi.org/10.1038/315425a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/315425a0
This article is cited by
-
Modelling of peptide and protein structures
Amino Acids (1994)
-
T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens
Nature (1988)
-
A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules
Nature (1988)
-
Recognition of multiple class II signals by murine T cell antigen receptors
Immunologic Research (1988)
-
The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens
Nature (1987)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
