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Association of histone H10 with a gene repressed during liver development

Nature volume 314, pages 197–198 (1985)Cite this article

Abstract

Histone H10 has a number of unusual properties that set it apart from other H1 subtypes (for review see ref. 1). For example, H10 synthesis is not strictly coupled to DNA synthesis2, it is absent from the embryonic liver of mice (but present shortly after birth)3,4 and its synthesis is hormone-dependent in some of the glands of adult rodents3. All the H1 subtypes differ in their DNA binding properties, and H10 has been shown to be preferentially associated with nuclease-resistant chromatin5. These features suggest that the H10 may have a role in developmental gene control. To investigate this further, we have fractionated the H10-containing nucleo-somes of chromatin from adult mouse liver. We report here that the gene for α-fetoprotein, which is expressed in embryonic tissue but repressed soon after birth6–9, is preferentially associated with the H10-containing nucleosomes. The related gene for albumin, which is expressed in both embryonic and adult tissues, is absent from the H10-containing nucleosome fraction. These results support a role for histone H10 in the control of gene expression.

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References

  1. Smith, B. J., Harris, M. R., Sigournay, C. M., Mayes, E. L. V. & Bustin, M. Eur. J. Biochem. 138, 309–317 (1984).

    Article  CAS  Google Scholar 

  2. Chabanas, A., Lawrence, J. J., Humbert, J. & Eisen, H. EMBO J. 2, 833–837 (1983).

    Article  CAS  Google Scholar 

  3. Gjerset, R., Gorka, C., Hasthorpe, S., Lawrence, J. J. & Eisen, H. Proc. natn. Acad. Sci. U.S.A. 79, 2333–2337 (1982).

    Article  ADS  CAS  Google Scholar 

  4. Larue, H., Bissonnette, E. & Beranger, L. Can. J. Biochem. cell. Biol. 61, 1197–1200 (1983).

    Article  CAS  Google Scholar 

  5. Gorka, C. & Lawrence, J. J. Nucleic Acids Res. 7, 347–359 (1979).

    Article  CAS  Google Scholar 

  6. Gorin, M. B. & Tilghman, S. M. Proc. natn. Acad. Sci. U.S.A. 77, 1351–1355 (1980).

    Article  ADS  CAS  Google Scholar 

  7. Kioussis, D. et al. J. biol. Chem. 256, 1960–1967 (1981).

    CAS  PubMed  Google Scholar 

  8. Tilghman, S. M. & Belayew, A. Proc. natn. Acad. Sci. U.S.A. 79, 5254–5257 (1982).

    Article  ADS  CAS  Google Scholar 

  9. Nahon, J. L., Gal, A., Frain, M., Sell, S. & Sala-Trepat, J. M. Nucleic Acids Res. 10, 1895–1911 (1982).

    Article  CAS  Google Scholar 

  10. Varshavsky, A. J., Bakayev, V. V., Nedospasov, S. A. & Georgiev, G. P. Cold Spring Harb. Symp. quant. Biol. 42, 457–473 (1978).

    Article  Google Scholar 

  11. Smith, B. J. & Johns, E. W. Nucleic Acids Res. 8, 6069–6079 (1980).

    Article  CAS  Google Scholar 

  12. Varshavsky, A. J., Bakayev, V. V. & Georgiev, G. P. Nucleic Acids Res. 3, 477–492 (1976).

    Article  CAS  Google Scholar 

  13. Smith, B. J. & Johns, E. W. FEBS Lett. 110, 25–29 (1980).

    Article  CAS  Google Scholar 

  14. Berent, S. L. & Sevall, J. S. Biochemistry 23, 2977–2983 (1984).

    Article  CAS  Google Scholar 

  15. Weintraub, H. Cell 38, 17–27 (1984).

    Article  CAS  Google Scholar 

  16. Hewish, D. R. & Burgoyne, L. A. Biochem. biophys. Res. Commun. 52, 504–510 (1973).

    Article  CAS  Google Scholar 

  17. Laemmli, U. K. Nature 277, 680–685 (1970).

    Article  ADS  Google Scholar 

  18. Maniatis, T., Fritsch, E. F. & Sambrook, J. in Molecular Cloning, A Laboratory Manual 331 (Cold Spring Harbor Laboratory, New York, 1982).

    Google Scholar 

  19. Maniatis, T., Jeffrey, A. & Van de Sande, H. Biochemistry 14, 3787–3794 (1975).

    Article  CAS  Google Scholar 

  20. Thomas, P. S. Proc. natn. Acad. Sci. U.S.A. 77, 5201–5205 (1980).

    Article  ADS  CAS  Google Scholar 

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  1. J. Roche

    Present address: Laboratoire de Biologie Moléculaire, Université Claude Bernard-Lyon 1, 43, Boulevard du 11 Novembre 1918, 69622, Villeurbanne Cedex, France

Authors and Affiliations

  1. Laboratoire de Biologie Moléculaire et Cellulaire, Département de Recherche Fondamentale, Centre d'Etudes Nucléaires de Grenoble, 85 X, 38041, Grenoble Cedex, France

    J. Roche, Cl. Gorka, P. Goeltz & J. J. Lawrence

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Roche, J., Gorka, C., Goeltz, P. et al. Association of histone H10 with a gene repressed during liver development. Nature 314, 197–198 (1985). https://doi.org/10.1038/314197a0

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