Abstract
The complete nucleotide sequence of two human T-cell leukaemia type III (HTLV-III) proviral DNAs each have four long open reading frames, the first two corresponding to the gag and pol genes. The fourth open reading frame encodes two functional polypeptides, a large precursor of the major envelope glycoprotein and a smaller protein derived from the 3′-terminus long open reading frame analogous to the long open reading frame (lor) product of HTLV-I and -II.
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References
Poiesz, B. J. et al. Proc. natn. Acad. Sci. U.S.A. 77, 7415–7419 (1980).
Kalyanaraman, V. S., Sarngadaharan, M. G., Bunn, P. A., Minna, J. D. & Gallo, R. C. Nature 294, 271–273 (1981).
Robert-Guroff, M., Ruscetti, F. W., Posner, L. E., Poiesz, B. J. & Gallo, R. C. J. exp. Med. 154, 1957–1964 (1981).
Yoshida, M., Miyoshi, I. & Hinuma, Y. Proc. natn. Acad. Sci. U.S.A. 79, 2031–2035 (1982).
Popovic, M. et al. Nature 300, 63–65 (1982).
Gallo, R. C. in Cancer Surveys (eds Franks, L. M., Wyke, J. & Weiss, R. A.) 113–159 (Oxford University Press, 1984).
Kalyanaraman, V. S. et al. Science 218, 571–573 (1982).
Chen, I. S. Y., McLaughlin, J., Gasson, J. C., Clark, S. C. & Golde, D. Nature 305, 502–505 (1983).
Gelmann, E. P., Franchini, G., Manzari, V., Wong-Staal, F. & Gallo, R. C. Proc. natn. Acad. Sci. U.S.A. 81, 993–997 (1984).
Popovic, M., Sarngadharan, M. G., Read, E. & Gallo, R. C. Science 224, 497–499 (1984).
Gallo, R. C. et al. Science 224, 500–502 (1984).
Schupbach, J. et al. Science 224, 503–505 (1984).
Sarngadharan, M., Popovic, M., Bruch, L., Schupbach, J. & Gallo, R. C. Science 224, 506–508 (1984).
Barre-Sinoussi, F. et al. Science 220, 868–871 (1983).
Gallo, R. C. et al. Proc. natn. Acad. Sci. U.S.A. 79, 4680–4683 (1983).
Popovic, M. et al. Science 219, 856–859 (1983).
Popovic, M., Lange-Watzin, G., Sarin, P. S., Mann, D. & Gallo, R. C. Proc. natn. Acad. Sci. U.S.A. 80, 5402–5406 (1983).
Gallo, R. C. et al. Cancer Res. 43, 3892–3899 (1983).
Wong-Stall, F., et al. Nature 302, 626–628 (1983).
Klatzmann, D. et al. Science 225, 59–63 (1984).
Chen, I. S. Y., Quan, S. G. & Golde, D. Proc. natn. Acad. Sci. U.S.A. 80, 7006–7009 (1983).
Hoshino, H. et al. Proc. natn. Acad. Sci. U.S.A. 80, 6061–6065 (1983).
Nagy, K., Clapham, P., Cheingong-Popov, R. & Weiss, R. A. Int. J. Cancer 32, 321–328 (1983).
Clapham, P., Nagy, K. & Weiss, R. A. Proc. natn. Acad. Sci. U.S.A. 81, 3082–3086 (1984).
Shaw, G. M. et al. Proc. natn. Acad. Sci. U.S.A. 81, 4544–4548 (1984).
Arya, S. K. et al. Science 225, 927–930 (1984).
Hahn, B. et al. Nature 312, 166–169 (1984).
Shimotohno, K., Golde, D. W., Miwa, M., Sugimura, T. & Chen, I. S. Y. Proc. natn. Acad. Sci. U.S.A. 81, 1079–1083 (1984).
Rho, H. M., Poeisz, B., Ruscetti, F. W. & Gallo, R. C. Virology 112, 355–360 (1981).
Yoshida, M., Miyoshi, I. & Hinuma, Y. Proc. natn. Acad. Sci. U.S.A. 79, 2031–2035 (1982).
Rey, M. A. et al. Biochem. biophys. Res. Commun. 111, 116–133 (1984).
Seiki, M., Hattori, S., Hirayama, Y. & Yoshida, M. Proc. natn. Acad. Sci. U.S.A. 80, 3618–3622 (1983).
Sagata, N. et al. Proc. natn. Acad. Sci. U.S.A. (in the press).
Haseltine, W. A., Sodroski, J. G. & Patarca, R. Curr. Topics Microbiol. Immun. 115 (in the press).
Haseltine, W. A. et al. Science 225, 419–421 (1984).
Shimotohno, K. et al. Proc natn. Acad. Sci. U.S.A. 81, 6657–6661 (1984).
Rice, N. R. et al. Virology 138, 82–93 (1984).
Sodroski, J., Rosen, C. & Haseltine, W. Science 225, 381–385 (1984).
Sodroski, J. et al. Science (in the press).
Celander, D. & Haseltine, W. Nature 312, 159–162 (1984).
Safai, B. et al. Lancet i, 1438–1440 (1984).
Laurence, J. et al. New Engl. J. Med. 311, 1269–1273 (1984).
Gottlieb, M. S. et al. New Engl. J. Med. 305, 1425–1431 (1981).
Essex, M. et al. in Human T-Cell Leukemia-Lymphoma Virus (eds Gallo, R. C., Essex, M. & Gross, L.) 355–362 (Cold Spring Harbor Laboratory, New York, 1984).
Miyoshi, I. et al. Nature 294, 770–771 (1981).
Yamamoto, N., Okada, M., Koyangi, Y., Kanagi, M. & Hinuma, Y. Science 217, 737–739 (1982).
Kinoshita, K. et al. in Adult T-Cell Leukemia Related Diseases (eds Hakaoka, M., Takatsuki, K. & Shimoyama, M.) 167–184 (Plenum, Tokyo, 1982).
Markham, P.D. et al. Int. J. Cancer 31, 413–420 (1983).
Groopman, J. E. et al. Science 226, 447–449 (1984).
Zagury, D. et al. Science 226, 449–451 (1984).
Ho, D. D. et al. Science 226, 451–453 (1984).
Gallo, R. C. & Wong-Staal, F. Blood 50, 545–557 (1982).
Shaw, G. M. et al. Science 226, 1165–1171 (1984).
Starcich, B. et al. Science (in the press).
Sodroski, J. et al. Proc. natn. Acad. Sci. U.S.A. 81, 4617–4621 (1984).
Sagata, N., Yasunaga, T., Ogawa, Y., Tsuzuka-Kawamura, J. & Ikawa, Y. Proc. natn. Acad. Sci. U.S.A. 81, 4751–4754 (1984).
Weiss, R., Teich, N., Varmus, H. & Coffin, J. (eds) RNA Tumor Viruses (Cold Spring Harbor Laboratory, New York, 1982).
Kitchen, L. et al. Nature 312, 367–369 (1984).
Oroszlan, S. et al. Proc. natn. Acad. Sci U.S.A. 79, 1291–1294 (1984).
Shinnick, T. M., Lerner, R. A. & Sutcliffe, J. G. Nature 293, 543–548 (1981).
Schwartz, D. E., Tizard, R. & Gilbert, W. Cell 32, 853–869 (1983).
Copeland, T. D., Oroszlan, S., Kalyanaraman, V. S., Sarngadaharan, M. G. & Gallo, R. C. FEBS Lett. 162, 390–395 (1983).
Bolognesi, D. P., Luftig, R. & Shaper, J. H. Virology 56, 549–564 (1973).
Smith, B. J. & Bailey, J. M. Nucleic Acids. Res. 7, 2055–2072 (1979).
Chiu, I-M., Tronick, S. R., Schlom, J. & Aaronson, S. A. Science 223, 364–370 (1984).
Patarca, R. & Haseltine, W. A. Nature 309, 728 (1984).
Levin, J. G., Hu, S. C., Rein, A., Messer, L. I. & Gerwin, B. I. J. Virol. 51, 470–478 (1984).
Von der Helm, K. & Duesberg, P. H. Proc. natn. Acad. Sci. U.S.A. 72, 614–618 (1975).
Vogt, P., Wight, W. & Eisenman, R. Virology 98, 154–167 (1979).
Dittmar, K. J. & Moelling, J. K. J. Virol 28, 106–118 (1978).
Schiff, R. D. & Grandgenett, D. P. J. Virol. 28, 279–291 (1978).
Herr, W. J. Virol. 49, 471–478 (1984).
Sodroski, J. et al. Science 225, 378–381 (1984).
Cianciolo, G. J., Kipnis, R. J. & Snyderman, R. Nature 311, 515 (1984).
Haseltine, W. A. & Patarca, R. Nature 309, 728 (1984).
Lenz, J., Crowther, R., Straceski, A. & Haseltine, W. A. J. Virol. 42, 519–529 (1982).
Bahl, O. P. & Shah, R. H. in The Glycoconjugates Vol. 1 (eds Horowitz, M. I. & Pigman, W.) 385–422 (Academic, New York, 1977).
Pinter, A. & Fleissner, E. Virology 83, 417–422 (1983).
Segrest, J. P. & Feldman, R. J. J. molec. Biol 87, 853–858 (1974).
Koch, W., Zimmerman, W., Oliff, A. & Friedrich, R. J. Virol. 49, 828–840 (1984).
Wachsman, W., Shimotohno, K., Clark, S. C., Golde, D. W. & Chen, I. S. Y. Science 226, 177–179 (1984).
Franchini, V., Wong-Staal, F. & Gallo, R. C. Proc. natn. Acad. Sci U.S.A. 81, 6207–6211 (1984).
Lee, T. H. et al. Science 226, 58–60 (1984).
Slamon, D. J., Shimotohno, K., Cline, M. J., Golde, D. W. & Chen, I. S. Y. Science 226, 61–63 (1984).
Rosen, C., Sodroski, J., Kettman, R., Burney, A. & Haseltine, W. A. Science (in the press).
Czernilofsky, A. P. et al. Nucleic Acids Res. 8, 2967–2984 (1980).
Essex, M. et al. Science 220, 859–862 (1983).
Essex, M. E. et al. Science 221, 1061–1064 (1983).
Dalgleish, A. et al. Nature 312, 763–766 (1984).
Weiss, R. A. et al. in Retroviruses in Human Lymphoma/Leukemia (ed. Miwa, M.) (Japan Sci. Soc. Press, Tokyo, in the press).
Maxam, A. M. & Gilbert, W. Meth. Enzym. 65, 499–560 (1980).
Sanger, F., Nickelen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).
Mount, S. M. Nucleic Acids Res. 10, 459–472 (1982).
Kyte, J. & Doolittle, R. F. J. molec. Biol. 157, 105–120 (1981).
Hopp, T. P. & Woods, K. R. Proc. natn. Acad. Sci. U.S.A. 78, 3824–3825 (1981).
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Ratner, L., Haseltine, W., Patarca, R. et al. Complete nucleotide sequence of the AIDS virus, HTLV-III. Nature 313, 277–284 (1985). https://doi.org/10.1038/313277a0
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DOI: https://doi.org/10.1038/313277a0
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