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Two steroid 21-hydroxylase genes are located in the murine S region

Nature volume 312, pages 465–467 (1984)Cite this article

Abstract

A common inherited disorder of steroidogenesis in man, 21-hydroxylase (21-OH) deficiency, is linked to the HLA major histocompatibility complex (MHC)1, and is associated in particular with certain allotypes of the HLA-linked complement proteins2,3. Recently, this disorder was demonstrated to result from a defective structural gene for the 21-OH enzyme, also termed cytochrome P-450C21 (ref. 4). The human (HLA) and murine (H–2) MHCs are homologous in overall organization and in the structures of their component genes5. To determine whether 21-OH genes are located in the H–2 complex, we have now used a bovine adrenal complementary DNA clone encoding part of 21-OH6 to examine a cluster of overlapping cosmid clones derived from the S region of the BALB/c mouse7. We found that there are two 21-OH genes in this region, located immediately 3′ to the C4 and Slp genes.

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Authors and Affiliations

  1. Laboratory of Human Immunogenetics, Memorial Sloan-Kettering Cancer Center, New York, New York, 10021, USA

    Perrin C. White & Bo Dupont

  2. Division of Pediatric Endocrinology, Department of Pediatrics, Cornell University Medical Center, New York, New York, 10021, USA

    Perrin C. White & Maria I. New

  3. Department of Genetics, Harvard Medical School, Boston, Massachusetts, 02115, USA

    David D. Chaplin, John H. Weis & J. G. Seidman

Authors
  1. Perrin C. White
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  2. David D. Chaplin
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  4. Bo Dupont
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  5. Maria I. New
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  6. J. G. Seidman
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White, P., Chaplin, D., Weis, J. et al. Two steroid 21-hydroxylase genes are located in the murine S region. Nature 312, 465–467 (1984). https://doi.org/10.1038/312465a0

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