Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Localization of insulin-like growth factor genes to human chromosomes 11 and 12

Nature volume 310, pages 784–786 (1984)Cite this article

Abstract

The insulin-like growth factors IGF-I and IGF-II are required for growth and development1–4. Both are single-chain proteins (of 70 and 67 amino acids respectively) derived from precursors by proteolytic processing5–6. IGF-I may be particularly important in promoting normal stature7 and IGF-II may be a fetal growth hormone8. The IGF proteins are probably synthesized by many normal tissues9 and by some tumours10. The secretion of growth factors by tumours and tumour-derived cell lines suggests that they may act as autocrine regulators of cell proliferation11. Because of the possible role of these proteins in growth disorders and cancer, and their sequence homology with insulin, we have determined their chromosomal localization. Using somatic cell hybrids12 and cloned cDNA probes6 for these proteins, we have assigned the genes for IGF-I and IGF-II to human chromosomes 12 and 11, respectively. We present evidence that the IGF-II gene is located on the short arm of chromosome 11 with a ras protooncogene and the insulin structural gene, and also suggest the existence of a fragment length polymorphism using the IGF-I probe.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Rinderkneckt, E. & Humbel, R. E. J. biol. Chem. 253, 2769–2776 (1978).

    Google Scholar 

  2. Rinderkneckt, E. & Humbel, R. E. FEBS Lett. 89, 283–286 (1978).

    Article  Google Scholar 

  3. Spencer, E. M. in Insulin-Like Growth Factors/ Somatomedins, Basic Chemistry, Biology, Clinical Importance (Walter de Gruyter, New York, 1983).

    Google Scholar 

  4. Clemmons, D. R. & Van Wyk, J. J. in Tissue Growth Factors (ed. Baserga, R.) 161–208 (Springer, Berlin, 1981).

    Book  Google Scholar 

  5. Jansen, M. et al. Nature 306, 609–611 (1983).

    Article  ADS  CAS  Google Scholar 

  6. Bell, G. I. et al. Nature 310, 775–777 (1984).

    Article  ADS  CAS  Google Scholar 

  7. Merimee, T. J., Zapf, J. & Froesch, E. R. New Engl. J. med. 305, 965–968 (1981).

    Article  CAS  Google Scholar 

  8. Moses, A. C. et al. Proc. natn. Acad. Sci. U.S.A. 77, 3649–3653 (1980).

    Article  ADS  CAS  Google Scholar 

  9. D'Ercole, A. J., Stiles, A. D. & Underwood, L. E. Proc. natn. Acad. Sci. U.S.A. 81, 935–939 (1984).

    Article  ADS  CAS  Google Scholar 

  10. Gordon, P., Hendricks, C. M., Kahn, C. R., Megyesi, K. & Roth, J. New Engl. J. Med. 305, 1452–1455 (1981).

    Article  Google Scholar 

  11. Sporn, M. B. & Todaro, G. J. New Engl. J. Med. 303, 878–880 (1980).

    Article  CAS  Google Scholar 

  12. Shows, T. B., Sakaguchi, A. Y. & Naylor, S. L. in Advances in Human Genetics Vol. 12 (eds Harris, H. & Hirschhorn, K.) 341–452 (Plenum, New York, 1982).

    Book  Google Scholar 

  13. Shows, T. et al. Somat. Cell molec. Genet. 10, 315–318 (1984).

    Article  CAS  Google Scholar 

  14. Shows, T. B. et al. Cytogenet. Cell Genet. 21, 99–104 (1978).

    Article  CAS  Google Scholar 

  15. Southern, E. M. J. molec. Biol. 98, 503–517 (1975).

    Article  CAS  Google Scholar 

  16. Woods, D. E., Markham, A. F., Ricker, A. T., Goldberger, G. & Collen, H. R. Proc. natn. Acad. Sci. U.S.A. 79, 5661–5665 (1982).

    Article  ADS  CAS  Google Scholar 

  17. Tricoli, J. V. & Shows, T. B. Somat. Cell molec. Genet. 10, 205–210 (1984).

    Article  CAS  Google Scholar 

  18. Naylor, S. L. et al. Somat. Cell Genet. 9, 609–616 (1983).

    Article  CAS  Google Scholar 

  19. Gerald, P. S. & Grzeschik, K. H. Cytogenet. Cell Genet. 37, 103–126 (1984).

    Article  CAS  Google Scholar 

  20. Roderick, T. H. et al. Cytogenet. Cell Genet. 37, 312–339 (1984).

    Article  CAS  Google Scholar 

  21. Zapf, J., Walter, H. & Froesch, E. R. J. clin. Invest. 68, 1321–1330 (1981).

    Article  CAS  Google Scholar 

  22. Waterfield, M. D. et al. Nature 304, 35–39 (1983).

    Article  ADS  CAS  Google Scholar 

  23. Downward, J. et al. Nature 307, 521–527 (1984).

    Article  ADS  CAS  Google Scholar 

  24. Jacobs, S. et al. J. biol. Chem. 258, 9581–9584 (1983).

    CAS  PubMed  Google Scholar 

  25. Waziri, M. et al. J. Pediat. 102, 873–876 (1983).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Human Genetics, Roswell Park Memorial Institute, 666 Elm Street, Buffalo, New York, 14263, USA

    James V. Tricoli & Thomas B. Shows

  2. Chiron Corporation, 4560 Horton Street, Emeryville, California, 94608, USA

    Leslie B. Rall & Graeme I. Bell

  3. Molecular Medicine Group, MRC Clinical Research Centre, Harrow, Middlesex, HA1 3UJ, UK

    James Scott

Authors
  1. James V. Tricoli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Leslie B. Rall
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. James Scott
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Graeme I. Bell
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Thomas B. Shows
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tricoli, J., Rall, L., Scott, J. et al. Localization of insulin-like growth factor genes to human chromosomes 11 and 12. Nature 310, 784–786 (1984). https://doi.org/10.1038/310784a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/310784a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing