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Tissue-specific activation of a cloned α-fetoprotein gene during differentiation of a transfected embryonal carcinoma cell line

Nature volume 310, pages 562–567 (1984)Cite this article

Abstract

To identify cis-acting DNA elements involved in the activation of the α-fetoprotein gene during differentiation, modified copies of the gene were introduced into murine F9 embryonal carcinoma cells. The differentiation of the transformants to either parietal or visceral endoderm was accompanied by induction of the exogenous template in a manner qualitatively, but not quantitatively, identical to that of the endogenous α-fetoprotein gene.

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Authors and Affiliations

  1. Institute for Cancer Research, 7701 Burholme Avenue, Philadelphia, Pennsylvania, 19111, USA

    Richard W. Scott, Thomas F. Vogt, Mary Ellen Croke & Shirley M. Tilghman

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  1. Richard W. Scott
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  2. Thomas F. Vogt
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  3. Mary Ellen Croke
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  4. Shirley M. Tilghman
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Scott, R., Vogt, T., Croke, M. et al. Tissue-specific activation of a cloned α-fetoprotein gene during differentiation of a transfected embryonal carcinoma cell line. Nature 310, 562–567 (1984). https://doi.org/10.1038/310562a0

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