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Histochemical changes in muscle of individuals with spinal cord injury following functional electrical stimulated exercise training

Abstract

Study Design: Longitudinal training. Objectives: To determine the effects of functional electrical stimulated (FES) leg cycle ergometer training on muscle histochemical characteristics in individuals with motor-complete spinal cord injury (SCI). Setting: University of Alberta, Edmonton, Alberta, Canada. Methods: Six individuals with motor-complete SCI (age 31–50 years; 3–25 years post-injury) trained using FES leg cycle ergometry for 30 min, 3 days per week for 8 weeks. Biopsies of the vastus lateralis muscle were obtained pre- and post-training and analyzed for fibre composition, fibre size and capillarization. Results: The majority of muscle fibres were classified as type 2 pre- and post-training. Average fibre area increased 23% (P<0.05) and capillary number increased 39% (P<0.05) with training. As a result of these proportional increases, capillarization expressed relative to fibre area was unchanged with training. Conclusions: FES leg cycle ergometer training results in proportional increases in fibre area and capillary number in individuals with SCI. Sponsorship: Supported by the Glenrose Rehabilitation Hospital.

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Chilibeck, P., Jeon, J., Weiss, C. et al. Histochemical changes in muscle of individuals with spinal cord injury following functional electrical stimulated exercise training. Spinal Cord 37, 264–268 (1999). https://doi.org/10.1038/sj.sc.3100785

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  • DOI: https://doi.org/10.1038/sj.sc.3100785

Keywords

  • capillarization
  • vastus lateralis
  • paraplegia
  • cycle ergometer

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