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Denervation releases a neuronal survival factor in adult rat hippocampus

Nature volume 308, pages 637–639 (1984)Cite this article

Abstract

Target-derived macromolecules in the peripheral nervous system apparently play an important part in the regulation of neuronal survival and maturation during critical stages of development1–7. Similar trophic factors could also be required in the central nervous system (CNS) for the maintenance of intracerebral connections, and neuronal cell death may result from a decrease or failure of a target-derived trophic support8,9. Recent experiments have demonstrated the presence of factors in brain extracts or astrocytic glial cells which can support the survival of embryonic sympathetic, parasympathetic or sensory ganglionic neurones in vitro10–14. The importance of these putative factors for neuronal survival in vivo has, however, so far not been demonstrated. In the study reported here we have used the intracerebral grafting technique to monitor the availability of survival factors in an adult CNS target area and show here that neonatal rat superior cervical cells, which have an absolute requirement for such factors for their survival1,2,3,15, will survive in the hippocampal formation of adult rats only in the presence of a denervating lesion.

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References

  1. Hendry, I. A. Rev. Neurosci. 2, 149–194 (1976).

    CAS  Google Scholar 

  2. Black, I. B. A. Rev. Neurosci. 1, 183–214 (1978).

    Article  CAS  Google Scholar 

  3. Varon, S. & Bunge, R. P. A. Rev. neurosci. 1, 327–361 (1978).

    Article  CAS  Google Scholar 

  4. Landmesser, L. & Pilar, G. Fedn. Proc. 37, 2016–2022 (1978).

    CAS  Google Scholar 

  5. Nishi, R. & Berg, D. K. Nature 277, 232–234 (1979).

    Article  ADS  CAS  Google Scholar 

  6. Henderson, C. E., Huchet, M. & Changeux, J. P. Nature 302, 609–611 (1983).

    Article  ADS  CAS  Google Scholar 

  7. Hill, M. A. & Bennett, M. R. Neurosci. Lett. 35, 31–35 (1983).

    Article  CAS  Google Scholar 

  8. Appel, S. H. Ann. Neurol. 10, 499–505 (1981).

    Article  CAS  Google Scholar 

  9. Hefti, F. Ann. Neurol. 13, 109 (1983).

    Article  CAS  Google Scholar 

  10. Lindsay, R. M. Nature 282, 80–82 (1979).

    Article  ADS  CAS  Google Scholar 

  11. Norrgren, G., Ebendal, T., Belew, M., Jacobson, C.-O. & Porath, J. Expl. Cell Res. 130, 31–38 (1980).

    Article  CAS  Google Scholar 

  12. Crutcher, K. A. & Collins, F. Science 217, 67–68 (1982).

    Article  ADS  CAS  Google Scholar 

  13. Barde, Y. A., Edgar, D. & Thoenen, H. EMBO J. 1, 549–553 (1982).

    Article  CAS  Google Scholar 

  14. Nieto-Sampedro, M. et al. Science 217, 860–861 (1982).

    Article  ADS  CAS  Google Scholar 

  15. Levi-Montalcini, R. & Angeletti, P. V. Physiol. Rev. 48, 534–568 (1968).

    Article  CAS  Google Scholar 

  16. Gage, F. H., Bjöklund, A. & Stenevi, U. Nature 303, 819–821 (1983).

    Article  ADS  CAS  Google Scholar 

  17. Bjöklund, A. & Stenevi, U. Brain Res. 229, 403–428 (1981).

    Article  Google Scholar 

  18. Loren, J., Björklund, A., Falck, B. & Lindvall, O. J. Neurosci. Meth. 2, 277–300 (1980).

    Article  CAS  Google Scholar 

  19. Abercrombie, M. Anat. Rec. 94, 239–247 (1946).

    Article  CAS  Google Scholar 

  20. Dahlström, A. thesis, Karolinska Institutet, Stockholm (1966).

  21. Loy, R. & Moore, R. Y. Expl. Neuronal. 57, 645–650 (1977).

    Article  CAS  Google Scholar 

  22. Stenevi, U. & Bjöklund, A. Neurosci. Lett. 7, 219–224 (1978).

    Article  CAS  Google Scholar 

  23. Crutcher, K. A. & Davis, J. N. Brain Res. 204, 410–414 (1981).

    Article  CAS  Google Scholar 

  24. Cowan, N. M. The Neuro sciences, 4th Study Program (eds Schmidt, F. O. & Woeden, F. G.) 59 (MIT Press, Cambridge, Massachusetts, 1979).

    Google Scholar 

  25. McCafferay, C. A., Bennett, M. R. & Dreher, B. Expl. Brain Res. 48, 377–386 (1982).

    Google Scholar 

  26. Ebendal, T., Olson, L., Seiger, Å. & Hedlund, K. O. Nature 286, 25–28 (1980).

    Article  ADS  CAS  Google Scholar 

  27. Vijayashankar, N. & Brody, H. J. Neuropath. exp. Neurol. 38, 490–497 (1979).

    Article  CAS  Google Scholar 

  28. Whitehouse, P. J. et al. Science 215, 1237–1239 (1982).

    Article  ADS  CAS  Google Scholar 

  29. Bondareff, W., Mountjoy, C. Q. & Roth, M. Neurology (NY) 32, 164–168 (1982).

    Article  CAS  Google Scholar 

  30. Pearson, R. C. A., Gatter, K. G. & Powell, T. P. S. Brain Res. 261, 321–325 (1983).

    Article  CAS  Google Scholar 

  31. Schmidt, R. H. et al. J. Neurochem. 38, 738–748 (1982).

    Article  Google Scholar 

  32. Da Prada, M. & Zurcher, G. Life Sci. 19, 1161–1174 (1976).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Histology, University of Lund, Biskopsgatan 5, S-223 62, Lund, Sweden

    Fred H. Gage, Anders Bjöklund & Ulf Stenevi

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  1. Fred H. Gage
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  2. Anders Bjöklund
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  3. Ulf Stenevi
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Gage, F., Bjöklund, A. & Stenevi, U. Denervation releases a neuronal survival factor in adult rat hippocampus. Nature 308, 637–639 (1984). https://doi.org/10.1038/308637a0

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