Abstract
Structural and functional homologies have been found among proteins encoded by several retroviral oncogenes, demonstrating the existence of families of these genes1. Because the retroviral oncogenes have cellular homologues1,2, the existence of similar families among these ‘cellular oncogenes’ is also implied (for a review, see ref. 2). Cellular genes belonging to these families have been found in such evolutionarily distant species as humans3,4, fruit flies5,6, nematodes5 and brewer's yeast (E. Scolnick and S. Reed, personal communications), consistent with the hypothesis that these genes have evolved from a small number of ancestral sequences2. We extend these observations by showing here that the proteins encoded by the oncogenes myc, myb and adenovirus E1a are structurally related. Our findings suggest that oncogenes of RNA and DNA tumour viruses may in at least some instances share evolutionary origins and function according to common principles.
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References
Bishop, J. M. & Varmus, H. E. RNA Tumor Viruses (eds Weiss, R., Teich, N., Varmus, H. E. & Coffin, J.) 999–1108 (Cold Spring Harbor, Laboratory, New York, 1982).
Bishop, J. M. A. Rev. Biochem. 52, 301–354 (1983).
Spector, D., Varmus, H. E. & Bishop, J. M. Proc. natn. Acad. Sci. U.S.A. 75, 4102–4106 (1978).
Dalla-Favera, R. et al. Proc. natn. Acad. Sci. U.S.A. 79, 6497–6501 (1982).
Shilo, B.-Z. & Weinberg, R. A. Proc. natn. Acad. Sci. U.S.A. 78, 6789–6792 (1981).
Simon, M. A., Kornberg, T. B. & Bishop, J. M. Nature 302, 837–839 (1983).
Alitalo, K. et al. Proc. natn. Acad. Sci. U.S.A. 80, 100–104 (1983).
Klempnauer, K.-H., Gonda, T. J. & Bishop, J. M. Cell 31, 453–463 (1982).
Dayhoff, M. O. et al. Protein Sequence Computer Database (National Biomedical Research Foundation, Washington DC, 1983).
Perricaudet, M., le Moullec, J. M. & Tiollais, P. Nature 288, 174–176 (1980).
Flint, S. J. DNA Tumor Viruses (ed. Tooze, J.) 547–576 (Cold Spring Harbor, Laboratory New York, 1980).
McLachlan, A. D. J. molec. Biol. 61, 409–424 (1971).
Perricaudet, M., Akusjarvi, G., Virtanen, A. & Petterson, U. Nature 281, 694–696 (1979).
Dijkema, R., Dekker, B. M. M. & van Ormondt, H. Gene 9, 141–156 (1980).
Colby, W. W., Chen, E. Y., Smith, D. H. & Levinson, A. D. Nature 302, 188–190 (1983).
Dayhoff, M. O. Atlas of Protein Sequence and Structure Vol. 5, Suppl. 3 (National Biomedical Research Foundation, Washington DC, 1978).
Rossman, M. J. & Argos, P. J. molec. Biol. 109, 99–129 (1977).
Wierenga, R. K. & Hol, W. G. J. Nature 302, 842–844 (1983).
Sauer, R. T., Yocum, R. R., Doolittle, R. F., Lewis, M. & Pabo, C. O. Nature 298, 447–451 (1983).
Delbaere, L. T. J., Hutcheon, W. L. B., James, M. N. G. & Theissen, W. E. Nature 257, 758–763 (1975).
Craik, C. S., Rutter, W. J. & Fletterick, R. J. Science 220, 1125–1131 (1983).
Greer, J. J. molec. Biol. 153, 1027–1042 (1981).
Lesk, A. & Chothia, C. J. molec. Biol. 136, 225–270 (1980).
Lesk, A. & Chothia, C. J. molec. Biol. 160, 325–342 (1982).
Chou, P. & Fasman, G. A. Rev. Biochem. 47, 251–276 (1978).
Doolittle, R. F. Science 214, 149–159 (1981).
Donner, P., Greiser-Wilke, I. & Moelling, K. Nature 296, 262–266 (1982).
Abrams, H. D., Rohrschneider, L. R. & Eisenman, R. N. Cell 29, 427–439 (1981).
Jochemsen, H. et al. Virology 122, 15–28 (1982).
Yee, S.-P., Rowe, D. T., Tremblay, M. K., McDermott, M. & Branton, P. E. J. Virol. 46, 1003–1013 (1983).
Feldman, L. T. & Nevins, J. R. Molec. Cell. Biol. 3, 829–838 (1983).
Land, H., Parada, L. F. & Weinberg, R. A. Nature 304, 596–602 (1983).
Ruley, H. E. Nature 304, 602–606 (1983).
Riccardi, R. P., Jones, R. L., Cepko, C. L., Sharp, P. A. & Roberts, B. E. Proc. natn. Acad. Sci. U.S.A. 78, 6121–6125 (1981).
Solnick, D. & Anderson, M. A. J. Virol. 42, 106–113 (1982).
Carlock, L. R. & Jones, N. C. J. Virol. 40, 657–664 (1981).
Jones, N. & Shenk, T. Cell 17, 683–689 (1979).
Ho, Y.-S., Galos, R. & Williams, J. Virol. 122, 109–124 (1982).
Babiss, L. E., Ginsberg, H. S. & Fisher, P. B. Proc. natn. Acad. Sci. U.S.A. 80, 1352–1356 (1983).
Watson, D. K., Reddy, E. P., Deusberg, P. H. & Papas, T. S. Proc. natn. Acad. Sci. U.S.A. 80, 2146–2150 (1983).
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Ralston, R., Bishop, J. The protein products of the myc and myb oncogenes and adenovirus E1a are structurally related. Nature 306, 803–806 (1983). https://doi.org/10.1038/306803a0
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DOI: https://doi.org/10.1038/306803a0
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