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Human gene for physical performance

Abstract

A specific genetic factor that strongly influences human physical performance has not so far been reported, but here we show that a polymorphism in the gene encoding angiotensin-converting enzyme does just that. An ‘insertion’ allele of the gene is associated with elite endurance performance among high-altitude mountaineers. Also, after physical training, repetitive weight-lifting is improved eleven-fold in individuals homozygous for the ‘insertion’ allele compared with those homozygous for the ‘deletion’ allele.

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Figure 1: Association of ACE alleles with performance.

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Montgomery, H., Marshall, R., Hemingway, H. et al. Human gene for physical performance. Nature 393, 221–222 (1998). https://doi.org/10.1038/30374

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