Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Inhibition of axonal growth by a monoclonal antibody


Little is known about factors which control the outgrowth of neurites in the central nervous system (CNS) during development, although in vitro studies with neurones from the peripheral nervous system have shown that neurites require an appropriate substrate1 and specific factors2,3 for growth. To investigate the role of cell-surface components in the development of the CNS, we have raised a series of monoclonal antibodies against membrane components of cells from the visual system of the chick embryo. We report here that one of these antibodies, T61/3/12, clearly inhibits axonal outgrowth from chick retinal explants but does not affect axon growth from the peripheral nervous system.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout


  1. Letourneau, P. C. Devl Biol. 44, 92–101 (1975).

    Article  CAS  Google Scholar 

  2. Levi-Montalcini, R. & Angeletti, P. U. Physiol. Rev. 48, 534–569 (1968).

    Article  CAS  Google Scholar 

  3. Barde, Y.-A., Edgar, D. & Thoenen, H. EMBO J. 1, 549–553 (1982).

    Article  CAS  Google Scholar 

  4. Halfter, W., Claviez, M. & Schwarz, U. Nature 292, 67–70 (1981).

    Article  ADS  CAS  Google Scholar 

  5. Saumweber, H., Symmons, P., Kabisch, R., Will, H. & Bonhoeffer, F. Chromosoma 80, 253–275 (1980).

    Article  CAS  Google Scholar 

  6. Fazekas de St. Groth, S. & Scheidegger, D. J. immun. Meth. 35, 1–21 (1980).

    Article  Google Scholar 

  7. Bonhoeffer, F. & Huf, J. EMBO J. 1, 427–431 (1982).

    Article  CAS  Google Scholar 

  8. Halfter, W., Newgreen, D. F., Sauter, J. & Schwarz, U. Devl Biol. (in the press).

  9. Rutishauser, U., Thiery, J.-P., Brackenbury, R., Sela, B.-A. & Edelman, G. M. Proc. natn. Acad. Sci. U.S.A. 73, 577–581 (1976).

    Article  ADS  CAS  Google Scholar 

  10. Chuong, C.-M., McClain, D. A., Streit, P. & Edelman, G. M. Proc. natn. Acad. Sci. U.S.A. 79, 4234–4238 (1982).

    Article  ADS  CAS  Google Scholar 

  11. Rutishauser, U., Gall, W. E. & Edelman, G. M. J. Cell Biol. 79, 382–393 (1978).

    Article  CAS  Google Scholar 

  12. Hausman, R. E. & Moscona, A. A. Expl Cell Res. 119, 191–204 (1979).

    Article  CAS  Google Scholar 

  13. Lemmon, V. & Gottlieb, D. I. J. Neurosci. 2, 531–535 (1982).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Henke-Fahle, S., Bonhoeffer, F. Inhibition of axonal growth by a monoclonal antibody. Nature 303, 65–67 (1983).

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI:

This article is cited by


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing