Abstract
Little is known about factors which control the outgrowth of neurites in the central nervous system (CNS) during development, although in vitro studies with neurones from the peripheral nervous system have shown that neurites require an appropriate substrate1 and specific factors2,3 for growth. To investigate the role of cell-surface components in the development of the CNS, we have raised a series of monoclonal antibodies against membrane components of cells from the visual system of the chick embryo. We report here that one of these antibodies, T61/3/12, clearly inhibits axonal outgrowth from chick retinal explants but does not affect axon growth from the peripheral nervous system.
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Henke-Fahle, S., Bonhoeffer, F. Inhibition of axonal growth by a monoclonal antibody. Nature 303, 65–67 (1983). https://doi.org/10.1038/303065a0
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DOI: https://doi.org/10.1038/303065a0
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