Abstract
Mating type interconversion has a precise lineage which serves to minimize the time taken for yeast cells to achieve the diploid state. The HO gene either encodes or regulates an endonuclease which initiates the interconversion process. Expression of this gene is switched on during the G1 phase of mother cells and not at all during the cell cycle of their daughters. This behaviour can explain what is known about the lineage.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Mortimer, R. K. & Hawthorne, D. C. in The Yeasts Vol. 1 (eds Rose, A. M. & Harrison, J. S.) 385 (Academic, New York, 1969).
Hawthorne, D. C. Abstr. Proc. 11th int. Congr. Genet. 7, 34–35 (1963).
Herskowitz, I. & Oshima, Y. in Molecular Biology of The Yeast Saccharomyces (eds Strathern, J. N., Jones, E. W. & Broach, J.) (Cold Spring Harbor Laboratory, New York, 1981).
Nasmyth, K. A. A. Rev. Genet. 16, 439–500 (1982).
Hicks, J. B. & Herskowitz, I. Genetics 83, 245–258 (1976).
Strathern, J. N. & Herskowitz, I. Cell 17, 371–381 (1979).
Strathern, J. N. et al. Cell 37, 183–192 (1982).
Nasmyth, K. A. Cell 30, 567–578 (1982).
Pringle, J. R. & Hartwell, L. H. in Molecular Biology of the Yeast Saccharomyces (eds Strathern, J. N., Jones, E. W. & Broach, J.) 97–142 (Cold Spring Harbor Laboratory, New York, 1981).
Jensen, R., Sprague, G. F. Jr & Herskowitz, I. Proc. natn. Acad. Sci. U.S.A. (in the press).
Thomas, P. S. Proc. natn. Acad. Sci. U.S.A. 77, 5201–5205 (1980).
Throm, E. & Duntze, W. J. Bact. 104, 1388–1390 (1970).
Hartwell, L. H. J. Bact. 115, 966 (1973).
Klar, A. J. S., Strathern, J. N. & Hicks, J. B. Cell 25, 517–524 (1981).
Hereford, L. M., Osley, M. A., Ludwig, J. R. & McLaughlin, C. S. Cell 24, 367–375 (1981).
Piñon, R. Chromosoma 67, 263 (1978); 70, 337 (1979).
Taketo, M., Jazwinski, S. M. & Edelman, G. M. Proc. natn. Acad. Sci. U.S.A. 77, 3144 (1980).
Haber, J. E. & Garvik, B. Genetics 87, 33–50 (1977).
Crandall, M. R., Egel, R. & MacKay, V. L. Adv. microb. Physiol. 15, 307–98 (1977).
Tatchell, K., Nasmyth, K. A., Hall, B., Astell, C. R. & Smith, M. Cell 27, 25–35 (1981).
O'Farrell, P. BRL Focus 3(3) 1 (1981).
Messing, J., Crea, R. & Seeburg, P. H. Nucleic Acids Res. 9, 309–321 (1981).
Duckworth, M. L. et al. Nucleic Acids Res. 9, 1691–1706 (1981).
Nasmyth, K. A., Tatchell, K., Hall, B. D., Astell, C. & Smith, M. Nature 289, 244–250 (1981).
Scherer, S. & Davis, R. W. Proc. natn. Acad. Sci. U.S.A. 76, 4951–4955 (1979).
Osley, M. A. & Hereford, L. Proc. natn. Acad. Sci. U.S.A. 79, 7689–7693 (1982).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nasmyth, K. Molecular analysis of a cell lineage. Nature 302, 670–676 (1983). https://doi.org/10.1038/302670a0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/302670a0
This article is cited by
-
Mating-type switching by homology-directed recombinational repair: a matter of choice
Current Genetics (2019)
-
Isolation of acdc28 mutation that abrogates the dependence of S phase on completion of M phase of the budding yeast cell cycle
Journal of Genetics (2000)
-
Secretion ofTrichoderma reesei β-glucosidase bySaccharomyces cerevisiae
Current Genetics (1996)
-
Yeast origin recognition complex is involved in DNA replication and transcriptional silencing
Nature (1993)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
