Abstract
Human T-cell leukaemia-lymphoma virus (HTLV) is an exogenous human retrovirus distinct from all known animal retroviruses. HTLV is closely linked to a subtype of adult T-cell malignancies and except for isolated cases, has not been found associated with any other form of leukaemia, lymphoma or other cancers (see refs 1, 2 for review). HTLV can be transmitted to cord blood T lymphocytes in vitro and the infected cells exhibit characteristics of transformed neoplastic T cells3–5. We have recently cloned DNA sequences derived from approximately 1 kilobase (kb) of the 5′ and 3′ termini of the HTLV genome, as well as a 4–5-kb defective HTLV provirus flanked by cellular sequences6. The availability of these probes has enabled us to carry out a limited survey of different fresh or cultured cells from patients of different lymphoid and myeloid malignancies for HTLV-related DNA sequences. The results presented here show that cells from all Japanese patients with adult T-cell leukaemia and several patients with various mature T-cell malignancies from elsewhere contained one or more copies of a highly conserved HTLV genome. The infected cells are of clonal origin. Fresh cells from 1 of the 10 myeloid leukaemic patients contained exogenous DNA sequences distantly related to HTLV.
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References
Gallo, R. C. & Wong-Staal, F. Blood 60, 545–557 (1982).
Gallo, R. C. et al. in Modem Trends in Human Leukemia V (ed. Neth, R.) (Springer, Munich, in the press).
Miyoshi, I. et al. Nature 294, 770–771 (1982).
Popovic, M. et al. Science 219, 856–859 (1983).
Markham, P. D. et al. J. Virol. (submitted).
Manzari, V. et al. Proc. natn. Acad. Sci. U.S.A. (in the press).
Yoshida, M., Miyoshi, I. & Hinuma, Y. Proc. natn. Acad. Sci. U.S.A. 79, 2031–2035 (1982).
Saxon, A., Stevens, R. H. & Golde, D. W. Ann. intern. Med. 88, 323–326 (1978).
Kalyanaraman, V. S. et al. Science 218, 571–573 (1982).
Gallo, R. C. et al. Cancer Res. (submitted).
Neel, B. G., Hayward, W. S., Robinson, H. L., Fang, J. & Astrin, S. M. Cell 23, 323–334 (1981).
Payne, G. S., Bishop, J. M. & Varmus, H. E. Nature 295, 209–213 (1982).
Kettmann, R. et al. Leukemia Res. 4, 509–519 (1981).
Manzari, V. et al. Proc. natn. Acad. Sci. U.S.A. 80, 11–15 (1983).
Hayward, W. S., Neel, B. G. & Astrin, S. M. in Advances in Viral Oncology Vol. 1 (ed. Klein, G.) 207–233 (Raven, New York, 1982).
Sarin, P. et al. Proc. natn. Acad. Sci. U.S.A. (in the press).
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Wong-Staal, F., Hahn, B., Manzari, V. et al. A survey of human leukaemias for sequences of a human retrovirus. Nature 302, 626–628 (1983). https://doi.org/10.1038/302626a0
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DOI: https://doi.org/10.1038/302626a0
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