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Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue

Nature volume 302, pages 33–37 (1983)Cite this article

Abstract

DNA sequence analysis of the activated oncogene from the T24 human bladder carcinoma line and two alleles of its normal cellular progenitor (c-Ha-ras-1) indicates that the genes encompass at least four exons, and that only a single point mutation residing within the first exon distinguishes the coding region of both alleles of the normal gene from their activated counterpart. Both versions o f the gene encode a protein which is predicted to differ from the corresponding viral gene product at three amino acid residues, one of which was previously shown to represent the major site of phosphorylation of the viral polypeptide.

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Authors and Affiliations

  1. Department of Molecular Biology, Genentech, Inc., 460 Point San Bruno Boulevard, South San Francisco, California, 49080, USA

    Daniel J. Capon, Ellson Y. Chen, Arthur D. Levinson, Peter H. Seeburg & David V. Goeddel

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  1. Daniel J. Capon
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  2. Ellson Y. Chen
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  3. Arthur D. Levinson
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  4. Peter H. Seeburg
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  5. David V. Goeddel
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Capon, D., Chen, E., Levinson, A. et al. Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue. Nature 302, 33–37 (1983). https://doi.org/10.1038/302033a0

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