Abstract
Peptides of the cholecystokinin family, but mainly the sulphated octapeptide (CCK8), have been found in brain extracts of several species1–6. High amounts are present in axons and nerve endings in the rat neostriatum (caudate-putamen)7,8 and a role for cholecystokinin as a neurotransmitter in this functionally important area is possible9,10. We have incubated slices of rat caudate-putamen (CP) to study the release of cholecystokinin-immunoreactivity (CCK-IR) in vitro. The release of CCK-IR was induced by veratridine. It was dependent on the presence of Ca2+ in the incubation medium and was blocked by tetrodotoxin. We now present evidence that dopaminergic agonists added to the slices modulate the veratridine-induced release via different groups of receptors. Receptors which mediate an enhancement of the release of CCK-IR seem to be located on afferent axons and nerve endings and are possibly of the D-2 subtype. Receptors which mediate an attenuation of the release are probably situated on cells intrinsic to the CP. These receptors seem to be coupled to adenylate cyclase and might thus be of the D-1 subtype. There is also evidence that endogenous dopamine when released enhances the secretion of CCK-IR.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Vanderhaeghen, J. J., Signeau, J. C. & Gepts, W. Nature 257, 604–605 (1975).
Dockrey, G. J. Nature 264, 568–570 (1976).
Dockrey, G. J., Gregory, R. A., Hutchinson, J. B., Ieuan Harris, J. & Runswick, M. J. Nature 274, 711–713 (1978).
Rehfeld, J. J. biol. Chem. 253, 4022–4030 (1978).
Ryder, S. W., Eng, J., Straus, E. & Yalow, R. S. Proc. natn. Acad. Sci. U.S.A. 78, 3892–3896 (1981).
Beinfeld, M. C., Meyer, D. K., Eskay, R. L., Jensen, R. T. & Brownstein, M. J. Brain Res. 212, 51–57 (1981).
Loren, I., Alumets, J., Hakansohn, R. & Sundler, F. Histochemistry 59, 249–257 (1979).
Vanderhaeghen, J. J., Lotstra, F., De May, J. & Gilles, C. Proc. natn. Acad. Sci. U.S.A. 77, 1190–1194 (1980).
Rehfeld, J. R., Goltermann, N., Larsson, L. I., Emson, P. M. & Lee, C. M. Fedn Proc. 38, 2325–2329 (1979).
Pinget, M., Straus, E. & Yalow, R. S. Life Sci. 25, 339–342 (1979).
Meyer, D. K., Beinfeld, M. C., Oertel, W. H. & Brownstein, M. J. Science 215, 187–188 (1982).
Coyle, J. T., Molliver, M. E. & Kuhar, M. J. J. comp. Neurol. 180, 301–324 (1978).
Schwarcz, R., Creese, T., Coyle, J. T. & Snyder, S. H. Nature 271, 766–768 (1978).
Kebabian, J. W. & Calne, D. B. Nature 277, 93–96 (1979).
Seeman, P. Pharmac. Rev. 32, 229–313 (1980).
Hyttel, J. Psychopharmacology 75, 217 (1981).
Kebabian, J. W., Petzold, G. L. & Greengard, P. Proc. natn. Acad. Sci. U.S.A. 69, 2145–2149 (1972).
Iversen, L. L. Science 188, 1084–1089 (1975).
Minneman, K. P., Quik, M. & Emson, P. C. Brain Res. 151, 507–521 (1978).
Krueger, B. K., Forn, J., Walters, J. R., Roth, R. H. & Greengard, P. Molec. Pharmac. 12, 639–648 (1976).
Burnstock, G. in Handbook of Psychopharmacology Vol. 5 (eds Iversen, L. L., Iversen, S. D. & der, S. H.) 131–194 (Plenum, New York, 1975).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Meyer, D., Krauss, J. Dopamine modulates cholecystokinin release in neostriatum. Nature 301, 338–340 (1983). https://doi.org/10.1038/301338a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/301338a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
