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Role of fimbrin and villin in determining the interfilament distances of actin bundles

Nature volume 301, pages 209214 (20 January 1983) | Download Citation

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Abstract

From X-ray diffraction patterns the interfilament distances of native and reconstituted actin bundles, and of purified actin gels subjected to a range of g forces by centrifugation, have been obtained and compared. The results suggest that bundling proteins, such as villin or fimbrin, cross-link actin filaments around a minimum distance probably set by electrostatic repulsion.

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Affiliations

  1. Max Planck Institute for Biophysical Chemistry, D-3400, Göttingen, FRG

    • Paul Matsudaira
    • , Lyndal K. Hesterberg
    •  & Klaus Weber
  2. Max Planck Institute for Medical Research, D-6900, Heidelberg, FRG

    • Eckhard Mandelkow
    •  & Winfried Renner
  3. Present address: MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, UK.

    • Paul Matsudaira

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https://doi.org/10.1038/301209a0

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