Letter | Published:

Absence of expression of OKT8 antigen on cultured human, calf and rat oligodendrocytes

Nature volume 301, pages 152154 (13 January 1983) | Download Citation

Subjects

Abstract

Monoclonal antibodies which recognize human suppressor T cells (OKT8) have been reported by Oger and co-workers to bind to cultured sheep oligodendrocytes1. These authors speculated that an immune response directed at determinants shared by suppressor lymphocytes and oligodendrocytes could explain the decrease in both circulating blood suppressor T cells2,3 and oligodendrocytes4 in patients with multiple sclerosis. In view of the vital issue of potential cross-reactivity between oligodendrocytes and lymphocytes, we studied the binding of viable cultured calf5, rat6 and human7 oligodendrocytes using monoclonal antibodies to human T cells and monocytes8. We report here that we were unable to confirm the presence of shared determinants among oligodendrocytes and any leukocytes, including human T cells or monocytes. As the reported observations of lymphocyte–oligodendrocyte shared determinants could not be identified in three other species, including man, we found no evidence to support the hypothesis that such shared determinants are of importance in the pathogenesis of multiple sclerosis.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , , & Nature 295, 66–68 (1982).

  2. 2.

    et al. New Engl. J. Med. 303, 125–129 (1980).

  3. 3.

    et al. Lancet ii, 1221–1222 (1980).

  4. 4.

    Pathobiol. Ann. 17, 347–384 (1977).

  5. 5.

    , , , & Brain Res. 223, 107–122 (1981).

  6. 6.

    , , & J. Neuropath, exp. Neuroi (in the press).

  7. 7.

    , , , & Neurology 32, A213 (1982).

  8. 8.

    & New Engl. J. Med. 303, 370–373 (1980).

  9. 9.

    et al. Nature 274, 813–816 (1978).

  10. 10.

    , & Lab. Invest. 43, 342–351 (1980).

  11. 11.

    , , & Soc. Neurosci. 7, 301 (1981).

  12. 12.

    , & , Neuroi. 11, 170–176 (1982).

  13. 13.

    et al. Neurology 32, A124 (1982).

  14. 14.

    , , , & Brain Res. 200, 151–164 (1980).

  15. 15.

    , , , & J. Neurochem. 37, 452–460 (1981).

  16. 16.

    , , & J. Neurocytol. (in the press).

  17. 17.

    , , & Nature 298, 375–377 (1982).

  18. 18.

    , , & J. Neurocytol. 7, 251–263 (1978).

  19. 19.

    et al. Brain Res. 174, 283–308 (1979).

Download references

Author information

Affiliations

  1. Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA

    • Mikio Hirayama
    • , Robert P. Lisak
    • , Seung U. Kim
    • , David E. Pleasure
    •  & Donald H. Silberberg

Authors

  1. Search for Mikio Hirayama in:

  2. Search for Robert P. Lisak in:

  3. Search for Seung U. Kim in:

  4. Search for David E. Pleasure in:

  5. Search for Donald H. Silberberg in:

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/301152a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.