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The virus of Japanese adult T-cell leukaemia is a member of the human T-cell leukaemia virus group

Nature volume 300, pages 63–66 (1982)Cite this article

Abstract

Human T-cell leukaemia virus (HTLV) has been isolated from several cases of cutaneous T-cell lymphoma in the United States1,2. Subsequently, adult T-cell leukaemia virus (ATLV) was also isolated from several cases of adult T-cell leukaemia in Japan3–5. Since the latter disease has been shown to be correlated ≥90% with the presence of high titred natural antibodies6–8 to two structural proteins of HTLV [p24 (ref. 9) and p19 (ref. 10)], it was important to compare HTLV and ATLV. We report here that by serology of p24 and p19 and by nucleic acid homology, ATLV appears to be as closely related to the original isolate of HTLV as different isolates of HTLV (from various regions of the world) are related to each other. ATLV is therefore either identical or closely related to HTLV.

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Authors and Affiliations

  1. Laboratory of Tumor Cell Biology, National Cancer Institute, NIH, Bethesda, Maryland, 20205, USA

    M. Popovic, M. S. Reitz Jr, M. Robert-Guroff & R. C. Gallo

  2. Department of Cell Biology, Litton Bionetics, Inc., 5516 Nicholson Lane, Kensington, Maryland, 20895, USA

    M. G. Sarngadharan & V. S. Kalyanaraman

  3. Department of Medicine, Kobe University School of Medicine, Kobe, Japan

    Y. Nakao

  4. Department of Internal Medicine, Kochi Medical School, Nankoku Kochi, 781-51, Japan

    I. Miyoshi

  5. Department of Immunology, Roswell Park Memorial Institute, Buffalo, New York, 14263, USA

    J. Minowada

  6. Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan

    M. Yoshida

  7. Department of Microbiology, Kyoto University, Faculty of Medicine, Kyoto, Japan

    Y. Ito

Authors
  1. M. Popovic
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  2. M. S. Reitz Jr
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  4. M. Robert-Guroff
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  5. V. S. Kalyanaraman
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  9. M. Yoshida
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  11. R. C. Gallo
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Popovic, M., Reitz, M., Sarngadharan, M. et al. The virus of Japanese adult T-cell leukaemia is a member of the human T-cell leukaemia virus group. Nature 300, 63–66 (1982). https://doi.org/10.1038/300063a0

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