Abstract
Interferons produce a variety of biological effects on cells. They induce resistance to virus proliferation1,2, inhibit cell growth3, modify cell structure and differentiation3–5, stimulate some immune functions and inhibit others6. However, the different interferon (IFN) species may vary in their mechanism of action and, hence, in their relative efficiency for inducing each of the effects. IFN-γ (type II) appears to show stronger immunoregulatory7–9 and growth inhibitory effects10–12 than antiviral effects13, but this conclusion has been challenged in other reports14. The aim of the present work is to compare the action of IFN-γ and other (type I) interferons on the induction of (2′–5′) oligo(A) synthetase which is probably part of the antiviral response15,16 and the induction of the histocompatibility HLA-A,-B,-C antigens17–19. We have shown previously that the induction of both proteins is regulated by interferons at the mRNA level20,21, but show here that IFN-γ from stimulated human lymphocytes22 and from monkey cells transfected by cloned human IFN-γ cDNA23 induced the HLA-A,-B,-C and β2-microglobulin mRNAs or proteins at concentrations over 100 times lower than those needed to induce the (2′–5′)oligo(A) synthetase and the antiviral state. This difference was not found with IFN-α and -β (type I).
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Wallach, D., Fellous, M. & Revel, M. Preferential effect of γ interferon on the synthesis of HLA antigens and their mRNAs in human cells. Nature 299, 833–836 (1982). https://doi.org/10.1038/299833a0
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DOI: https://doi.org/10.1038/299833a0
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