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An adenovirus glycoprotein binds heavy chains of class I transplantation antigens from man and mouse

Nature volume 299, pages 175–178 (1982)Cite this article

Abstract

The successful killing of virus-infected cells by cytotoxic T lymphocytes (CTL) is dependent on the recognition of both a viral product and class I antigens of the major histocompatibility complex (MHC) on the infected cell surface1–9. Whether these two entities are found independently on the cell surface and therefore recognized by two different CTL receptors, or whether they are associated together and can therefore be recognized by a single receptor is not known10. The association between an adenovirus-encoded glycoprotein expressed on the cell surface early after infection and class I antigens has been investigated and it has been found that antisera against class I antigens can co-precipitate the antigen and the viral glycoprotein from an adenovirus-transformed cell line from the Hooded-Lister rat strain11,12. We show here by in vitro affinity chromatography and in vivo immunoprecipitation that the viral glycoprotein specifically binds to the heavy chain of class I antigens in both man and mouse.

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Author notes

  1. Michael G. Katze

    Present address: Molecular Biology and Genetics, Unit of the Graduate School, Memorial Sloan-Kettering Cancer Center, New York, New York, 10021, USA

  2. Håkan Persson

    Present address: Laboratory of Molecular Genetics, National Institute of Child Health, and Human Development, Bethesda, Maryland, 20205, USA

  3. Lennart Philipson

    Present address: European Molecular Biology Laboratory, Postfach 10–2209, D–6900, Heidelberg, FRG

Authors and Affiliations

  1. Department of Microbiology, University of Uppsala, The Biomedical Center, Box 581, S-751 23, Uppsala, Sweden

    Christer Signäs, Michael G. Katze, Håkan Persson & Lennart Philipson

Authors
  1. Christer Signäs
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  2. Michael G. Katze
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  3. Håkan Persson
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  4. Lennart Philipson
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Signäs, C., Katze, M., Persson, H. et al. An adenovirus glycoprotein binds heavy chains of class I transplantation antigens from man and mouse. Nature 299, 175–178 (1982). https://doi.org/10.1038/299175a0

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