Reversion of a promoter deletion in yeast

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Abstract

Promoter function in yeast has been examined by obtaining revertants of a his3 promoter deletion in vivo. Events which provide a new promoter for the his3 gene include insertion of the transposable element Ty1, rearrangements of the plasmid vector, and chromosomal mutations. A role for dicentric chromosomes as a source of the plasmid rearrangements is discussed.

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References

  1. 1

    Scaife, J. & Beckwith, J. R. Cold Spring Harb. Symp. quant. Biol. 31, 403–408 (1966).

  2. 2

    Rosenberg, M. & Court, D. A. Rev. Genet. 13, 319–353 (1979).

  3. 3

    Losick, R. & Chamberlain, M. (eds) RNA Polymerase (Cold Spring Harbor Laboratory, New York, 1976).

  4. 4

    Roeder, G. S., Farabaugh, P. J., Chaleff, D. T. & Fink, G. R. Science 209, 1375–1380 (1980).

  5. 5

    Benoist, C. & Chambon, P. Nature 290, 304–310 (1981).

  6. 6

    Fromm, M. & Berg, P. Molec. cell. Biol. (in the press).

  7. 7

    Struhl, K. Proc. natn. Acad. Sci. U.S.A. 78, 4461–4465 (1981).

  8. 8

    Scherer, S. & Davis, R. W. Science 209, 1380–1384 (1980).

  9. 9

    Malone, R. & Esposito, R. Proc. natn. Acad. Sci. U.S.A. 77, 503–507 (1980).

  10. 10

    Clarke, L. & Carbon, J. Nature 287, 504–509 (1980).

  11. 11

    Stinchcomb, D. T., Mann, C. & Davis, R. W. J. molec. Biol. 158, 157–179 (1982).

  12. 12

    Jackson, J. A. & Fink, G. R. Nature 292, 306–310 (1981).

  13. 13

    Campbell, D. A. & Fogel, S. Genetics 85, 573–585 (1977).

  14. 14

    Cameron, J. R., Loh, E. Y. & Davis, R. W. Cell 16, 739–751 (1979).

  15. 15

    Errede, B., Cardillo, T. S. & Sherman, F. Cell 22, 427–436 (1980).

  16. 16

    Williamson, V. M. & Young, E. T. Cell 23, 605–614 (1981).

  17. 17

    Kingsman, A. J., Glimlich, R. L., Clarke, L., Chinnault, A. C. & Carbon, J. J. molec. Biol. 145, 619–632 (1981).

  18. 18

    Bach, M. L., Lacroute, F. & Botstein, D. Proc. natn. Acad. Sci. U.S.A. 76, 386–390 (1979).

  19. 19

    Anderson, P. & Roth, J. Proc. natn. Acad. Sci. U.S.A. 78, 3113–3117 (1981).

  20. 20

    Emmons, S. W., MacCosham, V. & Baldwin, R. L. J. molec. Biol. 91, 133–146 (1975).

  21. 21

    Strathern, J. N., Newlon, C. S., Herskowitz, I. & Hicks, J. B. Cell 18, 309–319 (1979).

  22. 22

    Ernst, J., Stewart, J. N. & Sherman, F. Proc. natn. Acad. Sci. U.S.A. 78, 6334–6338 (1981).

  23. 23

    Kassir, Y. & Herskowitz, I. Molec. gen. Genet. 180, 315–322 (1980).

  24. 24

    Nasmyth, K. A., Tatchell, K., Hall, B. D., Astell, C. & Smith, M. Nature 289, 244–250 (1981).

  25. 25

    Stinchcomb, D. T., Struhl, K. & Davis, R. W. Nature 282, 39–43 (1979).

  26. 26

    Orr-Weaver, T., Szostak, J. W. & Rothstein, R. J. Proc. natn. Acad. Sci. U.S.A. 78, 6354–6358 (1981).

  27. 27

    McClintock, B. Genetics 26, 234–282 (1941).

  28. 28

    Reynolds, A. E., Felton, J. & Wright, A. Nature 293, 625–629 (1981).

  29. 29

    Hayward, W. S., Neel, B. G. & Astrin, S. M. Nature 290, 475–480 (1981).

  30. 30

    Elder, R. T., St John, T. P., Stinchcomb, D. T. & Davis, R. W. Cold Spring Harb. Symp. quant. Biol. 45, 581–591 (1980).

  31. 31

    Proudfoot, N. & Maniatis, T. Cell 21, 537–545 (1980).

  32. 32

    Sakano, H., Huppi, K., Heinrich, G. & Tonegawa, S. Nature 280, 288–294 (1979).

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