Abstract
The serological recognition of ‘new’ gene products of the HLA system can be accomplished by selecting sera with strong leucocyte antibodies and testing these against a panel of cells obtained from donors which are compatible for the known HLA antigens with the antibody producer. This approach, which we termed the HLA-CAP approach (compatible with antibody producer), was essential in the recognition of what is now called the HLA–DR locus1 and of non HLA-linked T-cell subgroups2. Using the same technique, we have defined here several sera recognizing a structure on monocytes similar to one of the alleles of the HLA-linked PL33,4 or secondary B-cell (SB)5,6 system, so far only recognized by cellular techniques.
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van Leeuwen, A., Termijtelen, A., Shaw, S. et al. Recognition of a polymorphic monocyte antigen in HLA. Nature 298, 565–567 (1982). https://doi.org/10.1038/298565a0
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DOI: https://doi.org/10.1038/298565a0
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