Abstract
Despite intensive investigation, it remains unclear which receptor(s) on the B lymphocyte receives the signal(s) which leads to differentiation and antibody secretion. Binding of ligand (that is, specific antibodies) to the antigen receptors IgM or IgD, in the absence of T lymphocytes or their soluble products, leads to proliferation of normal B cells but not to antibody secretion1,2. Based on the observation that IgG Fc receptors (FcγR) have specific and unique interactions with other B-lymphocyte surface membrane molecules including I-region antigens3, IgM4 and IgD5, it was suggested that FcγR assist in regulation of B-lymphocyte responses5. Here we demonstrate that monoclonal antibodies specific for FcγR trigger normal B cells both to proliferate and to secrete antibody in the absence of T lymphocytes. These data suggest that the functional activation of B lymphocytes during normal immune responses may be mediated by FcγR.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Sieckmann, D. C. Immun. Rev. 52, 181–210 (1980).
Puré, E. & Vitetta, E. S. J. Immun. 125, 1240–1242 (1980).
Dickler, H. B. & Sachs, D. H. J. exp. Med. 140, 779–796 (1974).
Dickler, H. B. & Kubicek, M. T. J. exp. Med. 153, 1329–1343 (1981).
Dickler, H. B., Kubicek, M. T. & Finkelman, F. D. J. Immun. 128, 1271–1277 (1982).
Unkeless, J. C. J. exp. Med. 150, 580–596 (1979).
Mellman, I. S. & Unkeless, J.C. J. exp. Med. 152, 1048–1069 (1980).
Nussenzweig, M. C. et al. J. exp. Med. 154, 168–187 (1981).
Schimpl, A. & Wecker, E. Nature new Biol. 237, 15–17 (1972).
Parker, D. L. Immun. Rev. 52, 115–139 (1980).
Leibson, H. J., Marrack, P. & Kappler, J. W. J. exp. Med. 154, 1681–1693 (1981).
Kung, J. T., Sharrow, S. O., Mage, M. G. & Paul, W. E. J. Immun. (submitted).
Scher, I., Steinberg, A. D., Berning, A. K. & Paul, W. E. J. exp. Med. 142, 637–650 (1975).
Sinclair, N. R. S. & Chan, P. L. Adv. exp. Med. Biol. 12, 609–615 (1971).
Sidman, C. L. & Unanue, E. R. J. exp. Med. 144, 882–896 (1976).
Berman, M. A. & Weigle, W. O. J. exp. Med. 146, 241–256 (1977).
Morgan, E. L. & Weigle, W. O. J. exp. Med. 151, 1–11 (1980).
Morgan, E. L. & Weigle, W. O. J. Immun. 124, 1330–1335 (1980).
Morgan, E. L. & Weigle, W. O. J. exp. Med. 150, 256–266 (1979).
Segal, D. M., Sharrow, S. G., Jones, J. F. & Siraganian, R. P. J. Immun. 126, 138–145 (1981).
Lawrence, E. C., Blaesc, R. M., Martin, R. R. & Stevens, P. M. J. clin. Invest. 62, 832–835 (1978).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lamers, M., Heckford, S. & Dickler, H. Monoclonal anti-Fc IgG receptor antibodies trigger B lymphocyte function. Nature 298, 178–180 (1982). https://doi.org/10.1038/298178a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/298178a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
