Abstract
Although it has long been known that the hypothalamus contains substances which stimulate the release of adrenocorticotropic hormone (ACTH)1,2, corticoliberin (CRF) has only recently been identified and synthesized3,4. Here we describe the results of immunocytochemical staining of the neuroglandular system using an antiserum raised against this synthetic peptide. Neurone bodies containing CRF-like immunoreactivity (CLI) were stained in the paraventricular nuclei (PVN) of colchicine-injected rats whereas in normal rats, CLI was detected only in nerve fibres. These CLI-positive processes were abundant in the zona externa of the median eminence and in the pituitary stalk; they terminated close to capillaries of the primary portal plexus. In the rat fetus, CLI-containing fibres were detected only after the 18th day of development. After birth, a transitory disappearance of CLI was followed by its accumulation in fibres and perikarya. Morphological and physiological results corroborate recent biochemical studies 3,4; these will have to be taken into account in studies of the phenomena implicating participation of the adrenal cortex.
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Bugnon, C., Fellmann, D., Gouget, A. et al. Ontogeny of the corticoliberin neuroglandular system in rat brain. Nature 298, 159–161 (1982). https://doi.org/10.1038/298159a0
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DOI: https://doi.org/10.1038/298159a0
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