Abstract
The growth hormone release-inhibiting factor somatostatin was originally isolated and characterized from hypothalamic extracts1. Avian pancreatic polypeptide (APP) was first isolated from chicken pancreas2. Using antibodies raised against these peptides, both somatostatin-like3–5 and APP-like6,7 immunoreactivities have been found in many regions of the nervous system, and the peptides have been shown to coexist with catecholamines or other neuropeptides in certain neuronal systems8–11. In particular, we have recently reported that some neurones in the rat telencephalon contain both somatostatin- and APP-like immunoreactivities12. We present here immunohistochemical evidence that in the human cerebral cortex also, some neurones contain both immunoreactivities.
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Vincent, S., Johansson, O., Hökfelt, T. et al. Neuropeptide coexistence in human cortical neurones. Nature 298, 65–67 (1982). https://doi.org/10.1038/298065a0
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DOI: https://doi.org/10.1038/298065a0
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