Abstract
On emergence of the signal sequence of nascent secretory proteins from the large ribosomal subunit, translation is stopped by a cytoplasmic protein complex. A specific membrane protein of the endoplasmic reticulum, the ‘docking protein’, releases this block and allows further synthesis to be directly coupled to transfer across the membrane.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Milstein, C., Brownlee, G. G., Harrison, T. M. & Mathews, M. B. Nature new Biol. 239, 117–120 (1972).
Kreil, G. A. Rev. Biochem. 50, 317–348 (1981).
Sabatini, D. D., Kreibich, G., Morimoto, T. & Adesnik, M. J. Cell Biol. 92, 1–22 (1982).
Lingappa, V. R., Lingappa, J. R. & Blobel, G. Nature 281, 117–121 (1979).
Blobel, G. & Dobberstein, B. J. Cell Biol., 67, 835–851 (1975).
Blobel, G. & Sabatini, D. D. in Biomembranes (ed. Manson, L. A.) 193–195 (Plenum, New York, 1971).
Szczesna, E. & Boime, I. Proc. natn. Acad. Sci. U.S.A. 73, 1179–1183 (1976).
Bedouelle, H. et al. Nature 285, 78–81 (1980).
Talmadge, K., Stahl, S. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 77, 3369–3373 (1980).
Blobel, G. & Dobberstein, B. J. Cell Biol. 67, 852–862 (1975).
Prehn, S., Tsamalonkas, A. & Rapoport, T. Eur. J. Biochem. 107, 185–195 (1980).
Majzoub, J. A. et al. J. biol. Chem. 255, 11478–11483 (1980).
Lingappa, V. R., Katz, F. N., Lodish, H. F. & Blobel, G. J. biol. Chem. 253, 8667–8670 (1978).
Walter, P., Jackson, R. C., Marcus, M. M., Lingappa, V. R. & Blobel, G. Proc. natn. Acad. Sci. U.S.A. 76, 1795–1799 (1979).
Meyer, D. I. & Dobberstein, B. J. Cell Biol. 87, 498–502 (1980).
Meyer, D. I. & Dobberstein, B. J. Cell Biol. 87, 503–508 (1980).
Kreibich, G., Ulrich, B. L. & Sabatini, D. D. J. Cell Biol. 77, 464–506 (1977).
Warren, G. & Dobberstein, B. Nature 273, 569–571 (1978).
Dobberstein, B. Hoppe-Seyler's Z. physiol. Chem. 359, 1469–1470 (1978).
Walter, P. & Blobel, G. Proc. natn. Acad. Sci. U.S.A. 77, 7112–7116 (1980).
Walter, P. & Blobel, G. J. Cell Biol. 91, 557–561 (1981).
Meyer, D. I., Louvard, D. & Dobberstein, B. J. Cell Biol. 92, 579–583 (1982).
Revel, M. & Groner, Y. A. Rev. Biochem. 47, 1079–1126 (1978).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Meyer, D., Krause, E. & Dobberstein, B. Secretory protein translocation across membranes—the role of the ‘docking protein’. Nature 297, 647–650 (1982). https://doi.org/10.1038/297647a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/297647a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
