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Parental exposure to X rays and chemicals induces heritable tumours and anomalies in mice.

Nature volume 296, pages 575577 (08 April 1982) | Download Citation

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Abstract

Although radiation and various chemicals are known to produce mutations, there is a paucity of information on the production of germ-line mutations leading to heritable tumours and anomalies. I now report a significant and large increase in such tumours and anomalies following treatment of ICR parent mice with X rays and urethane. About 90% of the induced tumours were in the lung, and were inherited as if they were dominant mutations with about 40% penetrance.

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Author information

Affiliations

  1. Institute for Cancer Research, 1st Department of Surgery, and Department of Fundamental Radiology, Osaka University Medical School, Fukushima-ku, Osaka 553, Japan.

    • Taisei Nomura

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DOI

https://doi.org/10.1038/296575a0

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